Worthington Announcements

(last updated 12/13/16)


ASCB Survey Winner

Mei-Fong P. from Princetion University is the winner of the Worthington iPAD for participating in the recent 2016 ASCB annual meeting primary stem cell isolation survey held in San Francisco, CA. Congratulations to Mei and thanks to all survey participants!

For additional information on Worthington's products for neural cell isolation visit http://www.worthington-biochem.com/areas/ASCB.html

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Neuroscience Survey Winner

Kasper H. from University of Montana is the winner of the Worthington iPAD for participating in the recent 2016 SFN annual meeting primary stem cell isolation survey held in San Diego, CA. Congratulations to Kasper and thanks to all survey participants!

For additional information on Worthington's products for neural cell isolation visit http://www.worthington-biochem.com/areas/SFN.html

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Part Time Position

Position Filled - Thanks! 

 

Temporary Part-Time Vial Filler

Worthington Biochemical Corporation, a privately owned, ISO 9001-certified, Equal Opportunity Employer in Lakewood, NJ has an immediate opening for a Temporary (projected six months) Vial Filler (only). We seek an ethical, motivated, qualified individual for this part-time, non-exempt position. Salary is $14.50/hour. The selected candidate may work up to 20+ hours weekly, Monday through Friday. Flexible scheduling is possible after training is completed. 

 We are a primary manufacturer of high quality purified enzymes, proteins, nucleic acids and kits for biotech and life science research, diagnostic, pharmaceutical and bioprocessing applications. Our reputation of producing quality products for all types of life science applications is the result of almost 70 years of experience. Worthington’s in-house, full-service capabilities include initial extraction, fermentation, protein purification, lyophilization and packaging. 

 As our products are enzymes, they may be irritants to those with allergies. We provide all safety equipment, including safety glasses, gown, mask and gloves for the completion of this task. Good hand/eye coordination and attention to detail are required. The temporary vial filler will follow SOP’s to operate light machinery and sensitive scales as they fill hundreds of glass vials with our completed product. To qualify, applicants must have HS Diploma or equivalent, regularly use stairs, bend, and sometimes lift up to 20 pounds.

 Worthington Biochemical Corporation values safety and a drug-free workplace; drug testing is required. Team interviews will be conducted. Geographic proximity to our facility is preferable for this part-time, temporary position.

 Qualified candidates email resumes to hr@worthington-biochem.com by November 18, 2016. 

Marti Bookstein, SPHR, SHRM-SCP
HR Manager
Worthington Biochemical Corp.
730 Vassar Avenue
Lakewood, NJ 08701
732-942-1660 ext 23; 800-445-9603
Fax: 732-942-9270; 800-368-3108
hr@worthington-biochem.com


ISSCR Survey IPad Winner

Michelle T. from LifeNet Health in Virginia is the winner of the Worthington iPAD for participating in the 2016 ISSCR annual meeting primary stem cell isolation survey held in San Francisco, CA. Congratulations to Michelle and thanks to all survey participants!

For additional information on Worthington's products for stem cell isolation visit http://www.worthington-biochem.com/areas/REGEN.html

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Visit Worthington at ISSCR!

Worthington Biochemical will be exhibiting at the ISSCR meeting in San Francisco 6/22-26. Visit booth 1309 to learn more about our enzymes for primary stem cell isolation including STEMxyme® 1 and 2 and Celase® GMP Enzyme Blend for adipose stem cell isolation.  Also register for a chance to win an iPAD at Worthington's booth.

Celase® GMP grade enzyme blend information for adipose and other stem cell isolation applications, http://www.worthington-biochem.com/CLAS/cat.html 


Worthington Exhibiting at Immunology Annual Meeting

Worthington Biochemical will be exhibiting at the AAI (Immunology),http://www.immunology2016.org, annual meeting in Seattle, WA, 5/14-16. Come by booth #339 to discuss your enzyme needs for primary and stem cell isolation, DNA/RNA modification, protein sequencing, immunolabeling and more. Celase® GMP grade enzyme blend now available for adipose and other stem cell isolation applications, http://www.worthington-biochem.com/CLAS/cat.html


2016 Experimental Biology Survey Winner

Nishanth S. from University of Florida is the winner of the Worthington iPAD for participating in the 2016 Experimental Biology (EB) annual meeting primary cell isolation survey held in San Diego, CA. Congratulations to Nishanth and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Celase® GMP Collagenase Blend Now Available

Worthington Launches Celase® GMP an Avian and Mammalian Tissue-free Collagenase and Neutral Protease Enzyme Blend Produced Under GMP Guidelines

New enzyme grade is now available for use in a wide range of applications from initial animal research through clinical trials.

LAKEWOOD, NJ (April 5, 2016) – Worthington announced today at the Experimental Biology Conference in San Diego, the launch of the new Celase® GMP Enzyme product offering. Manufactured by Cytori Therapeutics, this product line is ideal for cell isolation studies for laboratories looking to facilitate a smooth transition from bench and animal research to downstream clinical applications. 

Celase® GMP is a proprietary enzyme containing a unique blend of collagenase, neutral protease and buffer salts that are produced using avian and mammalian tissue-free raw materials, aseptically processed, sterile filtered and highly purified under GMP guidelines. A single, sterile, ready to use enzyme containing both collagenase and a neutral protease is ideal for a wide range of adipose stem cell, biomedical and bioprocessing applications.

This new Celase® GMP product offering is a cost-effective option for laboratories looking for a high-quality GMP enzyme to support their pre-clinical research,” said James Zacka, vice president at Worthington.  “We believe the sooner a researcher recognize a potential for a clinical application it is to their long term regulatory benefit to qualify and use a GMP or equivalent grade of enzyme”

Not all research applications required the use a GMP grade enzyme in early phase studies. However, the recent FDA guidance issued for tissue and cell products specifically cite that GMP grade reagents should be used in drug-type validated processes. Subsequently, both regenerative medicine researchers and clinicians are now looking for GMP quality products with a smoother regulatory approval process as the goal. 

 “The Cytori Celase® Enzyme is currently used in US FDA approved clinical trials. We are excited to offer   a foundational and versatile enzyme for advancing adipose-based research programs from pre-clinical to clinical levels while eliminating the need to perform costly and time consuming bridging studies,” said Jason Streeter, quality engineer at Worthington.

About Worthington Biochemical Corporation
Founded in 1947, Worthington Biochemical Corporation is an industry leader in the development and production of high quality purified enzymes, proteins, nucleic acids and cell isolation kits for life science research, diagnostics and biotechnology applications.  An ISO9001 Certified, primary manufacturer Worthington meets enzyme requirements from research to scale-up bulk bioprocessing and OEM applications. Worthington Biochemical Corporation is a privately held company, headquartered in Lakewood, NJ and has worldwide distribution through a network of distributors.

 


Visit Worthington at Experimental Biology 2016

Worthington Biochemical will be exhibiting at the upcoming Experimental Biology annual meeting next week in San Diego, 4/2-4. Visit booth 921 to learn more about Worthington enzymes for life science research applications including Collagenases, animal free STEMxymes® and Celase® GMP Blends for primary and stem cell isolation, DNases, RNases, and many more. Participate in our survey for a chance to win a new iPad and pick up our latest product information.


2015 ASCB Survey Winner

Oscar Fernandez-Cazares from the University of California, Santa Cruz is the winner of the iPAD for participating in the 2015 ASCB annual meeting primary cell isolation survey held in San Diego, CA. Congratulations to Oscar and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Celase® Distribution Agreement

Worthington Biochemical Corporation Announces Expansion of GMP Compliant Enzyme Offering via Strategic Agreement with Cytori Therapeutics

Worthington Biochemical Corporation Signs a Non-exclusive, 3 Year Distribution Agreement for Cytori Celase® GMP Enzymes

LAKEWOOD, NJ (November 30, 2015) – Worthington announced today distribution rights to the Celase® GMP compliant enzyme from Cytori Therapeutics, San Diego, CA. The new Celase® GMP product offering allows Worthington customers focused on cell isolation studies to facilitate a smooth transition from bench and animal research to downstream clinical applications. 

Celase® GMP is a proprietary enzyme containing a unique blend of collagenase, neutral protease and buffer salts that are produced using avian and mammalian tissue-free raw materials, aseptically processed, sterile filtered and highly purified under GMP guidelines. A single, sterile, ready to use enzyme containing both collagenase and a neutral protease is ideal for a wide range of adipose stem cell, biomedical and bioprocessing applications. 

We are excited to offer Cytori’s Celase® GMP product to Worthington’s Collagenase and STEMxyme® portfolio for biomedical research and related bioprocessing applications. It was very important for us to find an enzyme that meets our stringent requirements for high quality and reproducible performance,” said Von Worthington, President and CEO at Worthington Biochemical Corporation.  “This new Celase® GMP product offering will be marketed through our catalog, direct sales force, distributor network, e-commerce website and upcoming scientific meetings.”

Cytori Therapeutics’ extensive product development expertise yields a best-in-class enzyme formulation providing researchers with superior and unparalleled convenience in their lab, clarity in their approach, and confidence in their results.

“We are very excited and pleased to initiate a partnership for Celase® GMP with a respected enzyme manufactured like Worthington which has decades of experience successfully serving the biomedical research and technology field,” said Russ Havranek, Director of Marketing at Cytori Therapeutics.

About Worthington Biochemical Corporation
Founded in 1947, Worthington Biochemical Corporation is an industry leader in the development and production of high quality purified enzymes, proteins, nucleic acids and cell isolation kits for life science research, diagnostics and biotechnology applications.  An ISO9001 Certified, primary manufacturer Worthington meets enzyme requirements from research to scale-up bulk bioprocessing and OEM applications. Worthington Biochemical Corporation is a privately held company, headquartered in Lakewood, NJ and has worldwide distribution through a network of exclusive distributors.
 

About Cytori Therapeutics

Cytori Therapeutics is a late stage cell therapy company developing autologous cell therapies from adipose tissue to treat a variety of medical conditions.  Data from preclinical studies and clinical trials suggest that Cytori Cell Therapy™ acts principally by improving blood flow, modulating the immune system, and facilitating wound repair.  As a result, Cytori Cell Therapy™ may provide benefits across multiple disease states and can be made available to the physician and patient at the point-of-care through Cytori’s proprietary technologies and products.  For more information visit www.cytori.com


Neuroscience Survey Winner

Thomas Shapaker of the University of Tennessee Health Sciences Center is the winner of the Worthington iPAD for participating in the 2015 Neuroscience (SFN) annual meeting neural cell isolation survey held in Chicaho, IL. Congratulations to Thomas and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


IFATS Conference Exhibit

 


Worthington will be exhibiting at the Society for Neuroscience meeting next week in Chicago, 10/18-21. Visit us at booth #1875 to learn about our products for primary neural cell isolation and research, and take our survey for a chance to Win an IPad!



CHI BioProcessing Conference

Worthington Biochemical will be exhibiting our Animal/Xeno Free Collagenases, STEMxyme® Collagenase/Neutral Protease Blends, DNases, RNases and other enzymes for primary stem cell isolation and bio=processing at the CHI Bioprocessing conference in Boston, 8/3-7, http://www.bioprocessingsummit.com

Please come by booth #401 to discuss your bioprocessing, primary & stem cell isolation enzyme needs.


2015 AACC Exhibit

Worthington will be exhibiting our enzymes and related biochemicals including clinical chemistry reagent grade enzymes, nucleases and proteases for molecular diagnostics and proteomics at the 2015 AACC (Clinical Chemistry) meeting in Atlanta, GA, 7/28-30. Please come by booth #4365 to discuss your research and bulk/OEM enzyme needs and pick up our new 2015-16 Product Catalog.


BIO Annual Meeting Exhibit

Worthington Biochemical will be exhibiting our Animal/Xeno Free Collagenases, STEMxyme® Collagenase/Neutral Protease Blends, DNases, RNases and other enzymes for primary stem cell isolation at the BIO annual meeting in Philadelphia, 6/16-18, booth #3009

Please come by to discuss Worthingon's capabilities relative to your enzyme needs.

 


ISCT 2015 Annual Meeting Exhibit

Worthington Biochemical will be exhibiting our Animal/Xeno Free Collagenases, STEMxyme® Collagenase/Neutral Protease Blends, DNases, RNases and other enzymes for primary stem cell isolation at the ISCT (Cell Therapy) Annual Meeting in Las Vegas, 5/27-29, https://lnkd.in/etdyMfg

Please come by to discuss your stem cell isolation enzyme needs.


New Improved Product Labeling

Please be advised that Worthington Biochemical will be implementing new and improved product labeling which will also be in compliance with OSHA’s Hazard Communication Standard, 29CFR 1910.1200 (HCS) to align with the UN Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

Worthington’s new label format will include all of the previous product label information in addition to the potential hazard requirements specified by the OSHA and GHS standards. 

This change is being implemented as a result of new OSHA and GHS standards and our ongoing continuous product and packaging improvement efforts. There will be no changes to existing products, processes or other packaging components.

Products with the new labeling will begin shipping this month and be fully implemented by June 1, 2015, as required by the GHS and OSHA regulations.  Please contact your Sales Representative or Worthington Customer or Technical Service if any additional information is required. 

 Thank you for your continued use of Worthington products. We also welcome your comments or feedback relative to these changes or any Worthington products.


Upcoming Exhibits and Meetings

Worthington will be exhibiting at the following upcoming meetings and suplier events:

DateMeetingLocationBooth
    
10/17/15 - 10/21/15Society for Neuroscience (SFN)Chicago, IL1875
11/05/15 - 11/08/15IFATS (International Federation for Adipose Therapeutics and Science)New Orleans, LA7
12/12/15 - 12/16/15American Society Cell Biology (ASCB)San Diego, CA628
04/02/16 - 04/05/16Experimental Biology (EB'16)San Diego, CA921
06/22/16 - 06/25/16International Society for Stem Cell Research )ISSCR)San Francisco, CA1309
08/02/16 - 08/04/16American Association for Clinical Chemistry (AACC)Philadelphia, PA3856

Come see us at these events. We welcome the opportunity to discuss your enzyme and related biochemical needs.  


AAI 2015 Survey Winner

Baohua Zhou from Indiana University School of Medicine is the winner of the Worthington iPAD for participating in the 2015 Immunology (AAI) annual meeting primary cell isolation survey held in New Orleans, LA. Congratulations to Baohua and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


EB 2015 Survey Winner

Rafaela Feresin from Florida State University is the winner of the Worthington iPAD for participating in the 2015 Experimental Biology (EB) annual meeting primary cell isolation survey held in Boston, MA. Congratulations to Rafaela and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Worthington Exhibiting at Experimental Biology 2015

Worthington Biochemical will be exhibiting at the 2015 Experimental Biology annual meeting in Boston, 3/29-31. We will be located in booth #701 exhibiting our enzymes and kits for primary neural, stem and other cell isolation with maximum yield, viability and biochemical response. Additional information is available at http://experimentalbiology.org/2015.aspx


Worthington Publishes 2015-16 Catalog & Product Guide Focused On

Catalog Features New Enzymes, Biochemicals and Primary Cell Isolation Kits

 

Worthington announced today the release of their 2015-16 catalog and product guide filled with an extensive product offering for scientific researchers across the globe. New and existing products are included for applications such as Primary Cell Isolation and Cell Culture, Protein Sequencing, Enzymology and Molecular Biology. 

“With the increasing demand for high quality, cost-effective tools for research, we are proud to release our 2015-16 edition of our product guide,” said Von Worthington President. “For over 65 years, Worthington has understood how researcher’s work and we use our expertise and extensive manufacturing experience to create tools to help them attain their results with a high level of confidence and quality assurance.”

 With an ongoing focus on new products, this new Worthington catalog include Animal Origin Free (AOF) STEMxyme® Collagenase/Neutral Protease (Dispase®) Blends, Collagenases, DNase, RNase T2 and other enzymes for regenerative medicine, biopharma and vaccine production applications. 

 Scientists can access the new catalog and product guide in multiple ways:

       Printed Version – Request a printed copy of the catalog  online.:   
http://www.worthington-biochem.com/mailinglist/request.php

       Digital Version – Visit to view the digital version of the catalog 


ASCB Survey Winner

Lauren Bailey from Texas A & M Iniversity is the winner of the iPAD for participating in the 2014 ASCB annual meeting primary cell isolation survey held in Philadelphia, PA. Congratulations to Lauren and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


2015 ASCB Meeting

Worthington Biochemical will be exhibiting at the American Society for Cell Biology (ASCB) annual meeting in San Diego, CA next week, 12/12-15. We will be located in booth #628 exhibiting our enzymes, collagenases, STEMxyme®, papain, trypsin, etc. and kits for primary neural, stem and other cell isolation with maximum yield, viability and biochemical response. Additional information is available at http://www.ascb.org/2015meeting/


Neuroscience 2014 Survey Winner

Laura Volpicelli-Daley is the winner of the iPad for participating in the 2014 Society for Neuroscience annual meeting primary neural cell isolation survey held in Washington, DC. Congratulations to Laura and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


2014 Neuroscience Meeting

Worthington Biochemical will be exhibiting at the Society for Neuroscience annual meeting in Washington DC next week, 11/15-19. We will be located in booth #2338 exhibiting our enzymes and kits for primary neural, stem and other cell isolation with maximum yield, viability and biochemical response. Additional information is available at http://www.worthington-biochem.com/default.html and http://www.sfn.org/annual-meeting/neuroscience-2014


GEN Basic Primary Cell Isolation Article

Genetic Enginerring News (GEN) has published an article from Worthington about Basic Cell Isolation, available at:

 http://www.genengnews.com/insight-and-intelligence/basic-primary-cell-isolation-for-nonperfusion-culture/77900296/


Worthington 2014 AACC Exhibit

Worthington will be exhibiting our enzymes and related biochemicals including clinical chemistry reagent grade enzymes, nucleases and proteases for molecular diagnostics and proteomics at the 2014 AACC (Clinical Chemistry) meeting in Chicago, IL, 7/29-31. Please come by booth #3641 to discuss your research and bulk/OEM enzyme needs.


ISSCR 2014 Survey Winner

Trudy Christiansen-Weber from the International Stem Cell Corporation in Carlsbad, CA is the winner of the iPad for participating at the 2014 ISSCR (stem cell research) international meeting primary stem cell isolation survey held in Vancouver. Congratulations to Trudy and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Tissue Dissociation Guide Now Available on iTunes

Worthington's current edition of the Tissue Dissociation Guide is now available as an ebook on iTunes, https://itunes.apple.com/us/book/tissue-dissociation-guide/id878827138?ls=1&mt=13

 This guide summarizes our knowledge of how enzymes accomplish "routine" operations of tissue dissociation and cell harvesting. Additionally, it describes standard lab procedures, offers a logical experimental approach for establishing a cell isolation protocol, and lists many tissue specific references. 

Requirements: This book was designed for iPad and some features may not work as intended with a mouse or trackpad. To view this book on an iPad, you must have iBooks 3 or later and iOS 5.1 or later. 


ISO Recertification Completed

Worthington is proud to announce our successful company-wide ISO9001:2008 recertification upon completion of the three year reassessment audit by ANAB-accredited SGS US Testing Company, Systems & Services Certification on 5/9/14.

Worthington Biochemical develops and produces high quality purified enzymes, proteins, nucleic acids and cell isolation kits for applications in life science research, diagnostics, bioprocessing, biopharm & biotechnology. Founded in 1947 and privately held, Worthington has maintained a reputation for quality products and excellent customer service which their ISO9001:2008 recertification confirms.

With worldwide distribution, Worthington markets products direct to domestic customers and internationally through a network of distributors. Products are supplied for primary cell isolation & cell culture, protein research, molecular biology and many other research applications. As a primary manufacturer, Worthington can meet enzyme requirements from research-scale to bulk bioprocessing quantities with all manufacturing taking place at their facility located in Lakewood, NJ. 

For additional information: Ph: 800.445.9603 • 732.942.0660, Fax: 800.368.3108, 732.942.9270 or visit www.worthington-biochem.com.

Contact: Jim Zacka, VP, ph: 732.942.1660, e-mail: jzacka@worthington-biochem.com


Immunology (AAI) 20114 Survey Winner

Laurel Kartchner of the UNC, Chapel Hill is the winner of the iPod for participating at the 2014 AAI (Immunology) meeting Enzyme Application survey held in Pittsburgh. Congratulations to Laurel and thanks to all survey participants!

Be sure to watch for additional Worthington surveys and contests at upcoming meetings and exhibits.


Worthington at Cell & Gene Therapy Forum January 27-29

Worthington will be exhibiting our Animal Origin Free Collagenases, STEMxyme® Collagenase/Neutral Protease Blends and other enzymes for primary stem cell isolation at the Phacilitate Cell & Gene Therapy Forum January 26-28 in Washington D.C. Collocated with the Washington Vaccine, Immunotherapy and Stem Cells as Discovery & Research Tools Forum 2015. Please come by to discuss your stem cell isolation enzyme needs.


Visit Worthington at IFATS Conference

Worthington will be participating at the IFATS Adipose Stem Cell conference 11/21-24 in NYC. Come by or visit our website to learn more about our new animal free STEMxyme™ Collagenase/Neutral Protease (Dispase®) Blends for primary and stem cell isolation.


Online Customer Satisfaction Survey Now Available

Worthington now has a brief online Customer Satisfaction Survey available for customers to provide feedback and comments about our products and service.

 

We invite you to complete our short Customer Satisfaction Survey  


Isolation of Human Atrial Myocytes for Simultaneous Measurements

Worthington is pleased to have sponsored the video publication of the following:

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+Transients and Membrane Currents, Voigt, N., Zhou, X. B., Dobrev, D., J. Vis. Exp. (), e50235, doi:10.3791/50235 (2013).

Short Abstract

We describe the isolation of human atrial myocytes which can be used for intracellular Ca2+ measurements in combination with electrophysiological patch-clamp studies. 

·       http://www.jove.com/video/50235/isolation-human-atrial-myocytes-for-simultaneous-measurements-ca2

·        http://www.jove.com/video/50235

 


New Products Update

Worthington is pleased to introduce the following new products now produced by Worthington:

STEMxyme® 1 & 2 Collagenase/Neutral Protease (Dispase) Blends, Animal Origin Free, for stem and primary cell isolation applications

Animal Origin Free Collagenase Types AFA, AFB and AFC, also available 0.22u filtered in 50mg vials for convenience

• Collagenase Type 5 containing higer collagenase and caseinase specific activities  

LowEndo™ Ovalbumin, ≥95% Purity, ≤1Endo U/mg

Endo-Arg-C (Clostripain), Sequencing Grade

Myoglobin, Bovine muscle

• Ribonuclease T2, Recombinant, Animal Origin Free, Purified 

See our updated product catalog listings for additional information on these and all Worthington products. 


ISO9001:2008 Certification

Worthington Biochemical Corporation is proud to announce their successful company-wide ISO9001:2008 upgrade recertification upon completion of the three year reassessment audit by ANAB-accredited SGS US Testing Company, Systems & Services Certification.

Worthington Biochemical develops and produces high quality purified enzymes, proteins, nucleic acids and cell isolation kits for applications in life science research, diagnostics, bioprocessing, biopharm & biotechnology. Founded in 1947 and privately held, Worthington has maintained a reputation for quality products and excellent customer service which their ISO9001:2008 recertification confirms.

With worldwide distribution, Worthington markets products direct to domestic customers and internationally through a network of distributors. Products are supplied for primary cell isolation & cell culture, protein research, molecular biology and many other research applications. As a primary manufacturer, Worthington can meet enzyme requirements from research-scale to bulk bioprocessing quantities with all manufacturing taking place at their facility located in Lakewood, NJ. 

For additional information: Ph: 800.445.9603 • 732.942.0660, Fax: 800.368.3108, 732.942.9270 or visit www.worthington-biochem.com.

Contact: Jim Zacka, VP, ph: 732.942.1660, e-mail: jzacka@worthington-biochem.com


Worthington #19 on NJBIZ New Jersey's Top Biotechnology Firms

Worthington Biochemical Corporation, Lakewood, NJ, has been listed as New Jersey's 19th largest biotechnology company in NJBIZ's October 5, 2009 issue.

Founded in 1947 by Charles Worthington and privately held, the company gained one spot in the ranking from the 2010 NJBIZ list, currently employing 55 in the Garden State.

Worthington is an ISO9001 certified producer of purified enzymes, proteins, nucleic acids and kits for life science research, diagnostic, biopharmaceutical, biotechnology and bioprocessing applications.

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NEW! Animal Origin Free Collagenase Grades Now Available!

Researchers interested in regenerative tissue applications and/or avoiding potential viral and prion risks from commonly used animal sourced fermentation media components now have Animal Origin Free (AOF) Collagenases produced by Worthington.

NEW! Types AFA, AFB ands AFC collagenase are derived from cultures grown in medium completely devoid of animal based components and designed for bioprocessing applications where introduction of potential animal derived pathogens must be prevented is now available from Worthington. Levels of secondary proteases are similar to Types 1 and 2 collagenase.

These new AOF types are also available 0.22 micron filtered and lyophilized in 50mg vials for single use convenience.

Several lots of AOF Collagenases are now available for sampling and evaluation in your specific application(s). Please contact Technical Service at 800.445.9603, e-mail: techservice@worthington-biochem.com or request samples on-line, Collagenase Sampling Program.

For more information.


Animal Free Recombinant (AF) DNase I Available!

Bovine pancreatic deoxyribonuclease I produced recombinantly in yeast, Pichia pastoris, to decrease levels of contaminating RNase and eliminate potential pathogens associated with animal based materials is now produced by Worthington.

Bovine pancreas is a rich source of RNase A which is often found in many commercial DNase preparations. Producing DNase I by recombinant means in an organism with much lower levels of endogenous RNase greatly facilitates purification of an enzyme with undetectable levels of RNase. The processes involved in the production and isolation of recombinant DNase I are completely devoid of animal based components which eliminates the possibility of introducing animal derived pathogens into bioprocessing procedures.

Recombinant DNase I is suitable for such applications as:
• Removing genomic DNA from RNA preparations prior to RT-PCR
• Degradation of DNA templates after transcription reactions
• Removing unwanted DNA from samples prior to Northern blotting
• Removing DNA during biopharma and bioprocessing procedures

For more information.


Collagenase Product(s) Raw Material Certification

Although it does not affect the majority of research customers, please be aware that the FDA has recently issued a 'Risk of BSE in Collagenase Enzymes' notice to all FDA-regulated users of Collagenases. (5/23/07 FDA Collagenase Note: PDF Version) Worthington currently provides Collagenase to many such customers for which this issue is likely to arise. We recently drafted a document (Collagenase Products Raw Material Certification) in response to the FDA's letter to all regulated Collagenase user, available on our website. Please note that although Worthington is not currently a cGMP manufacturer of collagenase we operate under GMP guidelines and are ISO9001:2000 Certified. In addition and most importantly, Worthington has never used Brain Heart Infusion (BHI) media in our collagenase production process. Other low-risk animal sourced raw materials are of USDA or equivalent inspected and approved as suitable for human consumption. We have also been working on developing a completely Animal Origin Free (AOF) collagenase product and have raised the priority of this due to recent inquiries such as this. We hope to have AOF Collagenase evaluation material available for sampling within a few months. We would welcome the opportunity to provide evaluation samples as soon as they become available if interested. Please let us know if we can be of additional assistance or if any additional information is required by any of your customers. We look forward to continuing to provide collagenase to meet the technical and regulatory requirements of the market.


HEPATOCYTE ISOLATION SYSTEM AVAILABLE!

Optimized and Functionally Tested Enzyme System For Hepatocyte Isolation
The Worthington Hepatocyte Isolation System has been developed to provide researchers with a reliable, convenient, and consistent hepatocyte cell isolation system. By using the pre-optimized combination of enzymes contained in this kit, it is possible to minimize the lot-to-lot variation and improve the quality of the isolated hepatocytes.

In addition, Worthington use-tests each lot by isolating hepatocytes from adult rat to assure performance, reliability, and consistent yield of viable cells. Each kit includes single-use enzyme vials, balanced salt solution, buffer, culture media and an optimized protocol for five separate adult rat liver perfusions. The method is based on that described by Berry, M.N., modified by Seglen, P.O., and further optimized in conjunction with several collaborating researchers.

Available on-line at www.worthington-biochem.com, e-mail: techservice@worthington-biochem.com , Call: 800.445.9603/732.942.1660 or Fax: 732-942-9270 for additional information!


Collagenase Lot Selection Tool Available Online!

Worthington's 'Collagenase Lot Selection Tool' is available online at our website. This new feature was designed to help researchers select and evaluate current collagenase lots that match previous lots or desired activity profiles. Users may enter target values for collagenase, caseinase, clostripan, and tryptic activities or specify previous lot numbers.

Each value can be weighted based on the relative level of importance to the application. After the search for matches is completed, a ranked list of collagenase lots currently available is generated. The selected lots can then be sampled simply by using the built in link to the Free Collagenase Sampling Program.

As always, Worthington Customer and Technical Service personnel are available via phone at 800.445.9603/732.942.1660 and e-mail to assist with collagenase or any other products.


Product Certificates of Analysis Available Online

Certificates of Analysis for any Worthington product are available online at our website, http://www.worthington-biochem.com.

This feature will enable customer's to instantly obtain a Certificate of Analysis with assay and descriptive information for any lot of Worthington product. Simply enter the desired lot number to obtain the current, lot-specific information. As always,

Worthington Customer and Technical Service personnel are available via phone at 800.445.9603/732.942.1660 and e-mail to assist with this or any other issues.


On-Line Ordering Now Available

Customers worldwide can now order Worthington products on-line through our new, easy to use on-line ordering system. Simply click the 'On-Line Ordering' link on our homepage and enter the requested information. As always, customer assistance and technical service is available BY PHONE: (732) 942-1660 or 1-800-445-9603, BY FAX: (732) 942-9270 or 1-800-368-3108 and e-mail.


NEW Primary Cell Isolation & Tissue Dissociation Guide Available

Worthington's latest 12th edition Tissue Dissociation Guide is available to assist researchers with selecting enzymes, developing and optimizing protocols and better understanding the process of enzymatic primary cell isolation and tissue dissociation.

The guide also discusses the enzymes most commonly used, their handling and specificity, and includes hundreds of new detailed cell and species-specific references. Available online at www.tissuedissociation.com
Request a copy online, by phone (800.445.9603 or 732.942.1660), or by Fax (732.942.9270).


New Tissue Dissociation Website

Worthington has launched a new website: www.tissuedissociation.com
It contains all information published in our popular Tissue Dissociation Guide. Also, annotated references ("Tissue Tables") will be updated regularly. You can use the Advanced Search feature to find references relevant to your research.