MATERIAL SAFETY DATA SHEET

SECTION 1 - CHEMICAL PRODUCT(S) AND COMPANY IDENTIFICATION
Manufacturer Name:Worthington Biochemical Corporation
Address:730 Vassar Ave
Lakewood, NJ 08701 USA
For Information Call:1-732-942-1660
Date Prepared:March, 1986
Date Revised:January, 2007
Date Reviewed:January, 2007

Quick Identifier (In-plant Common Name): Protein(s)/Enzyme(s)

Chemical Name: Enzyme/ProteinChemical Family: ProteinsFormula: Complex Polypeptides
Common Name/Trade Name: See List Below (Used on label)CAS Number: [As Listed]

Common Name/Trade Name (Used on label) Source CAS Number EC Number
Actin(rabbit muscle)N/AN/A
Adenosine Deaminase(calf spleen)[9026-93-1]3.5.4.4
Agarase, beta(Pseudomonas atlantica)[37288-57-6]3.2.1.81
Albumin(bovine)[9048-46-8]N/A
Alcohol Dehydrogenase(yeast)[9031-72-5]1.1.1.1
Aldolase(rabbit muscle)[9024-52-6]4.1.2.13
D-Amino Acid Oxidase(hog kidney)[9000-88-8]1.4.3.3
L-Amino Acid Oxidase(Crotalus adamanteus venom)[9000-89-9]1.4.3.2
alpha-Amylase(porcine pancreas)[9000-85-5]3.2.1.1
beta-Amylase(sweet potato)[9000-91-3]3.2.1.2
Arginase(bovine liver)[9000-96-8]3.5.3.1
L-Asparaginase(E. coli)[9015-68-3]3.5.1.1
Aspartate Aminotransferase(porcine heart)[9000-97-9]2.6.1.1
Avidin(egg white)[1405-69-2]N/A
Carbonic Anhydrase(bovine erythrocytes)[9001-03-0]4.2.1.1
Carboxypeptidase A(bovine pancreas)[11075-17-5]3.4.17.1
Carboxypeptidase B(bovine pancreas)[9025-24-5]3.4.17.2
Carboxypeptidase Y(yeast)[9046-67-7]3.4.16.1
alpha-Casein(bovine milk)[9000-71-9]N/A
Catalase(bovine liver)[9001-05-2]1.11.1.6
Cell Isolation Optimization System(see components)[9001-05-2]N/A
Cellulase(T. viride/reesei) N/A3.2.1.4
Cholesterol Esterase(porcine pancreas)[9026-00-0]3.1.1.13
Cholinesterase, Acetyl(E. electricus)[9000-81-1]3.1.1.7
Cholinesterase, Butryl(horse serum)[9001-08-5]3.1.1.8
Chymopapain(papaya latex)[9001-09-6]3.4.22.2
Chymotrypsin(bovine pancreas)[9004-07-3]3.5.21.1
Chymotrypsinogen A(bovine pancreas)[9035-75-0]N/A
Clostridiopeptidase A(Cl. histolyticum)[9001-12-1]3.4.24.3
Clostripain(Cl. histolyticum)[9028-00-6]3.4.22.8
Collagen(bovine achilles tendon)[9007-34-5]N/A
Collagen(soluble calf skin)[9007-34-5]N/A
Collagenese(Cl. histolyticum)[9001-12-1]3.4.24.3
Concanavalin A(Jack bean)[11028-71-0]N/A
Creatine Kinase(rabbit muscle)[9001-15-4]2.7.3.2
Cytochrome C Oxidase(bovine heart)N/A1.5.3.1
Deoxyribonunclease I(bovine pancreas)[9003-98-9]3.1.21.1
Deoxyribonuclease II(porcine spleen)[9025-64-3]3.1.22.1
Deoxyribonucleic Acid(calf thymus)[9007-49-2]N/A
Deoxyribonucleic Acid(Cl. perfringens)[9007-49-2]N/A
Deoxyribonucleic Acid(E. coli)[9007-49-2]N/A
Deoxyribonucleic Acid(Salmon testes)[9007-49-2]N/A
Deoxyribonucleic Acid, Activated(calf thymus)[9007-49-2]N/A
Deoxyribonucleic Acid-Celluloses(calf thymus)[9007-49-2]N/A
Deoxyribonucleic Acid, Lambda(E. coli)[9007-49-2]N/A
Deoxyribonucleic Acid, Lambda, bstE II(lambda-DNA)[9007-49-2]N/A
Deoxyribonucleic Acid, Lambda, EcoR I(lambda-DNA)[9007-49-2]N/A
Deoxyribonucleic Acid, Lambda, Hind III(lambda-DNA)[9007-49-2]N/A
Deoxyribonucleic Acid, Lambda, gt10(lambda-DNA)[9007-49-2]N/A
Deoxyribonucleic Acid, Lambda, gt11(lambda-DNA)[9007-49-2]N/A
Deoxyribonucleic Acid, Phage M-13(KO7/E. coli JV 30)[9007-49-2]N/A
Deoxyribonucleic Acid, T7(Bacteriophage T7, E. coli)[9007-49-2]N/A
Dextranase(Penicillium sp.)[9025-70-1]3.2.1.11
Diaphorase(Cl. kluyveri)[9001-18-7]1.6.99.1
DNA Ligase, T4(E. coli lysogenic NM989)[9015-85-4]6.5.1.1
DNA Polymerase(E. coli CM5199)[9012-90-2]2.7.7.7
DNAPolymerase, Klenow(E. coli CM5199)[9012-90-2]2.7.7.7
DNA Polymerase, Klenow, Exo-Free(E.coli CJ 375)[9012-90-2]2.7.7.7
DNA Polymerase, T4(E. coli T4 gene 43)[9012-90-2]2.7.7.7
DNA Polymerase, T4, Exo-Free(E. coli T4 gene 43 modified)[9012-90-2]2.7.7.7
DNA Polymerase, T7(E. coli T7 gene5/ thioredoxin)[9012-90-2]2.7.7.7
Elastase(porcine pancreas)[9004-06-2]3.4.21.36
Elastin(bovine ligamentum nuchae)[9007-58-3]N/A
Endonuclease V, T4(E. coli gene den V) N/AN/A
E-RASETM RNase A/T1 Blend(see components) N/AN/A
Galactose Oxidase(D. dendroides)[9028-79-9]1.1.3.4
beta-Galactosidase(E. coli)[9031-11-2]3.2.1.23
Glucose Oxidase(A. niger)[9001-37-0]1.1.3.4
Glucose-6-Phosphate Dehydrogenase(L. mesenteroides)[9001-22-3]1.1.1.49
beta-Glucosidase(almonds)[9001-22-3]3.2.1.21
alpha-Glucosidase(yeast)[9001-42-7]3.2.1.20
beta-Glucuronidase(bovine liver)[9001-45-0]3.2.1.31
Glutamate Decarboxylase(E. coli)[9024-58-2]4.1.1.15
Glutamic Oxaloacetic Transaminase(porcine heart)[9000-97-9]2.6.1.1
Glyceraldehyde-3-Phosphate Dehydrogenase(rabbit muscle)[9001-50-7]1.2.1.12
Glycerol Dehydrogenase(E. aerogenes)[9028-14-2]1.1.1.6
Glycerol Kinase(E. coli)[9030-66-4]2.7.1.30
Hemoglobin(bovine erythrocytes)[9008-02-0]N/A
Hepatocyte Isolation System(see components)N/AN/A
Hexokinase(yeast)[9001-51-8]2.7.1.1
Histones(calf thymus)[37244-51-2]N/A
Hyaluronic Acid(bovine vitreous humor)[9004-61-9]N/A
Hyaluronidase(bovine testes)[37326-33-3]3.2.1.35
Hydroxysteroid Dehydrogenase(P. testosteroni)[9028-56-2/9015-81-0]1.1.1.51
alpha-Lactalbumin(bovine milk)[9013-90-5]N/A
L-Lactate Dehydrogenase(baker's yeast)[9001-60-9]1.1.2.3
Lactate Dehydrogenase(bovine heart)[9001-60-9]1.1.1.27
Lactate Dehydrogenase(rabbit muscle)[9001-60-9]1.1.1.27
Lactoperoxidase(bovine milk)[9003-99-01.11.1.8
Leucine Aminopeptidase(porcine kidney)[9001-61-0]3.4.11.1
Lipase(porcine pancreas)[9001-62-1]3.1.1.3
Luciferase(P. fischerii)[9014-00-0]1.14.14.3
Lysozome(egg white)[12650-88-3]3.2.1.17
Malate Dehdrogenase(porcine heart)[9067-93-0]1.1.1.37
Maltase(yeast)[9001-42-7]3.2.1.20
Maltodextrin Phosphorylase(E. coli) N/AN/A
Micrococcus lysodeikticus cells(M. lysodeikticus) N/AN/A
Mucin(bovine submaxillary gland)[84195-52-8]N/A
NADase(N. crassa)[9032-65-9]3.2.2.5
Neonatal Cardiomyocyte Isolation System(see components) N/AN/A
Neuraminidase(Cl. perfringens)[9001-67-63.2.1.18
Nick Translation Kit(see components) N/AN/A
Nitrate Reductase(E. coli)[9029-42-9]1.9.6.1
Nuclease, Micrococcal (S7)(S. aureus)[9013-53-0]3.1.31.1
Nuclease, sI(A. oryzae)[37288-25-8]3.1.30.1
Nucleohistone(calf thymus)[37244-51-2]N/A
Oligo (dT)-Cellulose(oligo(dT)) N/AN/A
Ovalbumin(egg white)[9006-59-1]N/A
Papain(papaya latex)[9001-73-4]3.4.22.2
Papain Dissociation System(see components) N/AN/A
Papain, Mercuri-(papaya latex)[9001-73-4]3.4.22.2
Pectinase(A. niger)[9032-75-1]4.2.2.10
Pepsin(porcine stomach)[9001-75-6]3.4.23.1
Pepsinogen(porcine stomach)[9001-75-6] N/A
Peroxidase(horseradish roots)[9003-99-0]1.11.1.7
Phage DNA, M13(Phage M-13-KO7 E. coli JV30)[9007-49-2]N/A
Phosphate, Acid(wheat germ)[9001-77-8]3.1.3.2
Phosphatase, Alkaline(calf intestine)[9001-78-9]3.1.3.1
Phosphatase, Alkaline(chicken intestine) [9001-78-9]3.1.3.1
Phosphatase, Alkaline(E. coli) [9001-78-9]3.1.3.1
Phosphodiesterase I(Crotalus adamanteus venom)[9025-82-5]3.1.4.1
Phosphodiesterase II(bovine spleen)[9068-54-6]3.1.4.18
Phosphoenolpyruvate Carboxylase(E. coli)[9067-77-04.1.1.31
Phosphoglucomutase(rabbit muscle)[9001-81-4]5.4.2.2
Phospholipase A2(Crotalus adamanteus venom)[9001-84-7]3.1.1.4
Phospholipase C(Cl. perfringens)[9001-86-9]3.1.4.3
Plasma Amine Oxidase(bovine plasma)[9001-53-0]1.4.3.6
Plasmid DNA, pBR322(E. coli RLM 430)[9007-49-2]N/A
Plasmid DNA, pt7-0 UD(E. coli DH5-a) [9007-49-2]N/A
Plasmid DNA, pT7-1(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pT7-2(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pT7-7(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pT7-SC(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pT7-SCII(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pTZ18U(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pTZ19U(E. coli DH5-a)[9007-49-2]N/A
Plasmid DNA, pUC 18(E. coli DHP5-a)[9007-49-2]N/A
Plasmid DNA, pUC 19(E. coli DHP5-a)[9007-49-2] N/A
Plasmid DNA, pUC 118(E. coli DHP5-a)[9007-49-2] N/A
Plasmid DNA, pUC 119(E. coli DHP5-a)[9007-49-2] N/A
Pokeweed Antiviral Protein(Phytolacca americana (pokeweed))[63231-57-2]N/A
Polynucleotide Kinase, T4(E. coli T4)[37211-65-7]2.7.1.78
Polyphenol Oxidase (Tyrosinase)(mushroom)[9002-10-2]1.14.18.1
Protease, Neutral (Dispase)(B. polymyxa)[9001-92-7]3.4.24.6
Protease, V8(S. aureus)[66676-43-5]3.4.21.19
Proteinase K(T. album)[39450-01-6]3.4.21.14
Pyruvate Kinase(rabbit muscle) [9001-59-6] 2.7.1.40
Random Primers  N/A N/AN/A
Reverse Transcriptase, HIV, Recombinant (E. coli plasmid pRC-RT) [9068-38-6] 2.7.7.49
Ribonucleic Acid (baker's yeast) [63231-63-0] N/A
Ribonucleic Acid, Core (brewer's yeast) [63231-63-0]  N/A
Ribonucleic Acid, Q-beta Phage (Phage Q-beta) [63231-63-0]  N/A
Ribonuclease A (bovine pancreas) [9001-99-4] 3.1.27.5
Ribonuclease B (bovine pancreas) [9001-99-4] 3.1.27.5
Ribonuclease T1 (A. oryzae[9026-12-4] 3.1.27.3
RNA Polymerase (E. coli 4-13) [9014-24-8] 2.7.7.6
RNA Polymerase, T7 (E. coli T7 gene) [9014-24-8] 2.7.7.6
(Hydroxy) Steroid Dehydrogenase (P. testosteroni[9028-56-2/9015-81-0] 1.1.1.51
Superoxide Dismutase (bovine erythrocytes) [9054-89-1] 1.15.1.1
Thymidine Phosphorylase (E. coli[9030-23-3]2.4.2.4
Trypsin (bovine pancreas) [9002-07-7] 3.4.21.4
Trypsinogen (bovine pancreas) [9002-07-7] N/A
Trypsin Inhibitor (bovine pancreas) [9035-81-8] N/A
Trypsin Inhibitor (lima bean) [9035-81-8]N/A
Trypsin Inhibitor (ovomucoid) [9035-81-8] N/A
Trypsin Inhibitor (soybean) [9035-81-8] N/A
Tyrosine Decarboxylase (Str. faecalis[9002-09-9] 4.1.1.25
Urease (Jack bean) [9002-13-5] 3.5.1.5
Uricase  (C. utilis[9002-12-4] 1.7.3.3
Uricase (porcine liver) [9002-12-4]1.7.3.3
Xanthine Oxidase (bovine milk)[9002-17-9] 1.2.3.2

SECTION 2 - COMPOSITION AND INFORMATION ON INGREDIENTS
Ingredient Name(s): Refer to Section 1CAS Number(s): Refer to Section 1
Principal Hazardous Component(s): N/AChemical & common name(s): Enzymes, Proteins
Biologic Activity: Varies(%)EC Number(s): Refer to Section 1
Exposure Limit(s): Not Established (Enzymes/Proteins may cause allergic reactions in certain sensitive individuals)

SECTION 3 - HAZARDS IDENTIFICATION
Threshold Limit Value: None Known or Reported
Signs and Symptoms of Exposure:
  1. Acute Overexposure: May cause skin, eye or respiratory irritation upon contact
  2. Chronic Overexposure: Allergic reactions may develop in certain sensitive individuals
Medical Conditions Generally Aggravated by Exposure: Allergy-prone and asthmatic individuals should be particularly cautious with enzymes and other materials of biologic origin
Chemicals Listed as Carcinogen or Potential Carcinogen: No
National Toxicology Program: No
I.A.R.C. Monographs: No
OSHA: No
OSHA Permissible Exposure Limit: No
ACGIH Threshold Limit Value: N/A
Other Exposure Limit Use: N/A

SECTION 4 - FIRST AID MEASURES
Emergency and First Aid Procedures (Enzymes/Proteins may cause allergic reactions in certain sensitive individuals)
  1. Inhalation: Remove person from source then obtain necessary medical attention
  2. Eyes: Check for contact lenses and remove if present. Flush thoroughly with water while opening eyelids. If symptoms such as redness and irritation persist, obtain medical attention
  3. Skin: Remove contaminated clothing. Wash material from skin with soap and water and rinse thoroughly with clean water. Obtain medical attention as needed or if irritation develops. Clean contaminated clothing before reuse.
  4. Ingestion: May be harmful if swallowed. Obtain medical attention as needed.

SECTION 5 - FIRE AND EXPLOSION HAZARDS
Special Fire Fighting Procedures: None
Auto-Ignition Temperature: N/A
Flash Point: N/A
Flammable Limits in Air (% by Volume): N/A
Extinguisher Media: N/A
Unusual Fire and Explosion Hazards: None
Stability: Degradation products are not hazardous

SECTION 6 - ACCIDENTAL RELEASE MEASURES
Precautions to be Taken in Handling and Storage: Wear appropriate protective equipment
Other Precautions: None

Steps to be Taken in Case Material in Release or Spilled: Wear approved respirator and protective gloves. Vacuum or collect powdered spill into appropriate waste container for disposal. Avoid physical contact and dust during removal. Use normal clean-up procedures for liquid spillage and wash thoroughly with water. Wash contaminated clothing before reuse.

Waste Disposal Method: Dispose of waste in accordance with all applicable Federal, State and local regulations. Refer to Section 13.

SECTION 7 - HANDLING & STORAGE
Storage: Refer to specific product label for storage conditions. Lyophilized proteins will absorb moisture under high humidity and/or moisture conditions. Keep containers tightly closed when not in use and store in a cool, dry area according to label conditions. Long-term storage temperatures should not exceed 25ºC for maximum stability.

Handling: Minimize dust and/or aerosol generation during use. Dry powders can build static electricity cause by excessive handling. Wear appropriate protective equipment as per Section 8.

SECTION 8 - EXPOSURE CONTROLS & PERSONAL PROTECTION
Respiratory Protection (Specify Type): A protective dust mask is advisable to avoid breathing particulates when a powdered form of the product is being handled. Wear an appropriate respirator
Mechanical (General): Vent Fan
Ventilation: Advisable
Local Exhaust: As Required
Special: None
Protective Gloves: Wear glove to prevent skin contact
Eye Protection: Either safety glasses or goggles should be worn
Other Protective Clothing or Equipment: Sensitive individuals should wear dust masks/respirators, protective gloves, eye protection, lab coat, apron or other protective clothing to minimize contact.

SECTION 9 - PHYSICAL & CHEMICAL PROPERTIES
Appearance and Odor:Powders - White to tan, typical enzyme odor
Liquids - White to brown, typical enzyme odor
Solubility in Water:Powders - Appreciable
Liquids - readily miscible in water
Boiling Point: Decomposes
Specific Gravity(H2O=1): Varies
Vapor Pressure (mmHg): N/A
Percent Volatile by Volume: N/A
Vapor Density(Air=1): N/A
Evaporation Rate: N/A

SECTION 10 - STABILITY & REACTIVITY
Hazardous Decomposition Products: None Known
Hazardous Polymerization: Will Not Occur
Incompatability(Materials to Avoid): None Known

SECTION 11 - TOXICOLOGICAL INFORMATION
Refer to Section 3 for health effects information. The toxicological properties of this material have not been fully investigated. Always follow Good Laboratory and Industrial Hygiene Practices and wear proper personal protective equipment when handling chemicals. May cause irritation and/or allergic reaction(2).

Routes of Exposure: Inhalation, ingestion, skin and eye contact.
LD50: No oral LD50 is available
Carcinogenicity: Unknown
Mutagenic/Teratogenic Effects: Unknown

SECTION 12 - ECOLOGICAL INFORMATION
No data available. No environmental hazard is known.

SECTION 13 - DISPOSAL CONSIDERATIONS
Dispose of waste in accordance with all applicable Federal, State and local regulations. chemical residues are generally classified as special waste and, as such, the transportation, storage, treatment and disposal of this waste material must be conducted in compliance with all applicable Federal, State and local regulations. Rinse empty containers thoroughly before disposal and/or recycling.

SECTION 14 - TRANSPORT INFORMATION
Department of Transportation Requirements:Proper Shipping Name:Not Regulated
Hazard Class:N/A
Packaging Group:N/A
Reportable Quantity:N/A
Labels Required:N/A
International Transportation Regulations: Not RegulatedUN/NA Code: N/A

SECTION 15 - REGULATORY INFORMATION
US Federal Regulations: Material(s) listed are exempt from the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory when supplied for research and development purposes or used under the Supervision of a technically qualified individual as defined by 40 CFR720.3. The health risks have not been fully determined.

State Regulations: Based upon available information, material(s) listed are not known to be regulated by any state or listed on the New Jersey Right To Know Hazardous Substance List.

International Regulations: EC: Harmful; R42/43, May cause sensitization by inhalation and skin contact. S36, Wear suitable protective clothing.

SECTION 16 - OTHER USEFUL INFORMATION
Disclaimer
The information contained in this MSDS relates only to the material(s) designated and does not relate to use(s) in combination with any other material, process(es) and/or chemical reaction(s). Worthington Biochemical, Inc. provides this information in good faith, from sources believed to be accurate; however, Worthington assumes no liability for its accuracy or completeness.

All Worthington products are supplied for manufacturing, research and laboratory use only. Researchers and laboratory personnel intending to use any of these produced for medical investigation on humans are solely responsible for such use and for compliance with the pertinent regulations of the United States Food & Drug Administration (US-FDA) and other regulations. We do not assume liability for damages resulting from the handling, use and/or disposal of these products, from their use in violation of patent or other rights or reliance upon this information.

Worthington Biochemical Corporation
730 Vassar Ave
Lakewood, New Jersey 08701 USA
Phone: 800-445-9603/732-942-1660 | Fax: 800-368-3108/732-942-9270

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