Histones

The histones are a group of water- and dilute acid-soluble basic proteins found associated with DNA in chromosomes. They are characterized by relatively high levels of lysine and arginine. Although histones are classified into a limited number of types of fractions with each particular fraction having a fundamentally distinct amino acid composition and sequence, numerous subfractions are observed due to the acetylation, methylation and phosphorylation of various amino acid residues.

Technical Note: Histones are characterized by gel electrophoresis and solubility. Soluble in physiological saline, phosphate buffered saline (PBS) pH 7.1, or water when pH is adjusted to neutral.

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