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Tissue References Search Tool

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Brain
Rat
Rat, SD, 7 day
Tanaka, S. , Shaikh, I. , Chiocca, E. and Saeki, Y.
The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells During Postnatal Development. ,
PLoS ONE
 4 , e5922 , 2009
Cells
Cerebellar granule neurons
Enzymes
PDS kit : per instructions
Medium
PBS
Brain
Rat
Rat, Wistar, 14 day
Mizoguchi Y, Kanematsu T, Hirata M, Nabekura J.
A rapid increase in the total number of cell surface functional GABAA receptors induced by brain-derived neurotrophic factor in rat visual cortex ,
J Biol Chem
 278 , 44097 , 2003
Cells
Visual cortical
Enzymes
PDS kit : per instructions
Medium
EBSS
Brain
Rat
Rat, SD, E16
Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Velicelebi G, Johnson EC.
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5 ,
J Pharmacol Exp Ther
 290 , 170 , 1999
Cells
Cortical neurons
Enzymes
PDS kit : with modifications
Medium
Neurobasal Medium
Brain
Rat
Rat, E18
Naeve GS, Ramakrishnan M, Kramer R, Hevroni D, Citri Y, Theill LE.
Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis ,
Proc Natl Acad Sci U S A
 94 , 2648-53 , 1997
Cells
Hippocampal and cortical neurons
Enzymes
PDS kit : per instructions
Medium
Neurobasal media
Endothelial
Rat
Rat, Wistar, male, 3 mo
Nagelkenke, J. , Barto, K. and VanBerkel, T.
In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells ,
J Biol Chem
 258 , 12221 , 1983
Cells
Endothelial
Kupffer
Parenchymal
Enzymes
Collagenase : 0.05%
Pronase : 0.25%
Medium
HBSS
Epithelial
Rat
Rat, SD, male, 150 - 250 g
Dial, E. , Kao, Y. and Lichtenberger, L.
Effects of 16,16-Dimethyl Prostaglandin E2 On Glycoprotein And Lipid Synthesis of Gastric Epithelial Cells Grown in a Primary Culture ,
In Vitro Cell Dev Biol
 27 , 39 , 1991
Cells
Epithelial
Stomach
Enzymes
Pronase : 0.15%
Medium
Medium 199
Epithelial
Rat
Rat, Fisher 344, male, 8 wks old,
250-300 g
Chang, L. , Wu, R. and Nettesheim, P.
Morphological Changes in Rat Tracheal Cells During The Adaptive and Early Growth Phase in Primary Cell Culture ,
J Cell Sci
 74 , 283 , 1985
Cells
Tracheal epithelial
Enzymes
Pronase : 0.5%
Medium
DMEM
Eye
Rat
Adult, female, 170-200 g
Mead, B. and Tomarev, S.
Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms. ,
Stem Cells Transl Med
 6 , 1273-1285 , 2017
Cells
Retinal
Enzymes
PDS kit : with modifications
Medium
EBSS
Eye
Rat
Rat, SD, 6-8 week
Vigneswara, V. , Esmaeili, M. , Deer, L. , Berry, M. , Logan, A. and Ahmed, Z.
Eye Drop Delivery of Pigment Epithelium-Derived Factor-34 Promotes Retinal Ganglion Cell Neuroprotection and Axon Regeneration. ,
Mol Cell Neurosci
 68 , 212-21 , 2015
Cells
Retinal
Enzymes
PDS kit : per instructions
Medium
EBSS
Eye
Rat
Rat, SD
Tan, C. , Andrews, M. , Kwok, J. , Heintz, T. , Gumy, L. , Fassler, R. and Fawcett, J.
Kindlin-1 Enhances Axon Growth on Inhibitory Chondroitin Sulfate Proteoglycans and Promotes Sensory Axon Regeneration. ,
J Neurosci
 32 , 7325 , 2012
Cells
Retinal ganglion
Enzymes
PDS kit : with modifications
Medium
Neurobasal
Eye
Rat
Rat, Fisher, adult
Suzuki, T. , Mandai, M. , Akimoto, M. , Yoshimura, N. and Takahashi, M.
The Simultaneous Treatment of MMP-2 Stimulants in Retinal Transplantation Enhances Grafted Cell Migration into the Host Retina. ,
Stem Cells
 24 , 2406 , 2006
Cells
Retinal
Enzymes
PDS kit : per instructions
Medium
MEM
Eye
Rat
Rat, Dark Agouti, 3-4 week
Akagi T, Mandai M, Ooto S, Hirami Y, Osakada F, Kageyama R, Yoshimura N, Takahashi M.
Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue ,
Inv Ophthal Visual Sci
 45 , 4570 , 2004
Cells
Ciliary-derived eye
Enzymes
PDS kit : with modifications
Medium
DMEM/F12
Heart
Rat
Rat, SD, 8-10 week
Lee, J. , Ha, J. and Leem, C.
A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca(2+) Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat. ,
Korean J Physiol Pharmacol
 19 , 373-82 , 2015
Cells
Ventricular myocytes
Enzymes
Collagenase : 0.08%
Pronase : 0.004%
Medium
Tyrode's Solution
Liver
Rat
Rat, SD
Handy, J. , Saxena, N. , Fu, P. , Lin, S. , Mells, J. , Gupta, N. and Anania, F.
Adiponectin Activation of AMPK Disrupts Leptin-Mediated Hepatic Fibrosis via Suppressors of Cytokine Signaling (SOCS-3). ,
J Cell Biochem
 110 , 1195 , 2010
Cells
Hepatic stellate cells
Enzymes
Pronase : 0.02%
Collagenase : see reference
Medium
Medium 199
Liver
Rat
Rat, Wistar, female
Zvibel, I. , Atias, D. , Phillips, A. , Halpern, Z. and Oren, R.
Thyroid Hormones Induce Activation of Rat Hepatic Stellate Cells Through Increased Expression of p75 Neurotrophin Receptor and Direct Activation of Rho. ,
Lab Invest
 90 , 674 , 2010
Cells
Hepatic stellate cells
Enzymes
Collagenase Type 1 : 0.025-0.1%
Pronase : 0.025-0.13%
Medium
DMEM
Liver
Rat
Rat, SD, 500-750 g
Li, Z. , Dranoff, J. , Chan, E. , Uemura, M. and Sevigny, J.and Wells, R.
Transforming Growth Factor-beta and Substrate Stiffness Regulate Portal Fibroblast Activation in Culture. ,
Hepatol
 46 , 1246-56 , 2007
Cells
Portal fibroblasts
Enzymes
Collagenase : 0.03%
Pronase : 0.033%
Hyaluronidase : 0.036%
Medium
DMEM/F-12
Liver
Rat
Rat, adult
Jensen C. , Jauho E. , Santoni-Rugiu E. , Holmskov U. , Teisner B. , Tygstrup N. and Bisgaard H.
Transit-amplifying Ductular (oval) Cells and Their Hepatocytic Progeny are Characterized by a Novel and Distinctive Expression of Delta-like Protein/preadipocyte Factor 1/fetal Antigen 1 ,
Am J Pathol
 164(4) , 1347 , 2004
Cells
Hepatocytes
Enzymes
Pronase : 1%
Medium
Williams E
Liver
Rat
Rat, CD strain, albino, male, 140 -180 g
Braun, L. , Mead, J. , Panzica, M. , Mikumo, R. , Bell, G. and Fausto, N.
Transforming Growth Factor B mRNA Increases During Liver Regeneration:A Possible Paracrine Mechanism Of Growth Regulation ,
Proc Natl Acad Sci U S A
 85 , 1539 , 1988
Cells
Hepatocytes and Nonparenchymal
Enzymes
Pronase : 0.1%
Medium
HEPES buffer with calcium
Liver
Rat
Rat, Wistar, male, 3 month old
Nagelkenke, J. , Barto, K. and VanBerkel, T.
In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells ,
J Biol Chem
 258 , 12221 , 1983
Cells
Endothelial
Kupffer
Parenchymal
Enzymes
Collagenase : 0.05%
Pronase : 0.25%
Medium
HBSS
Neural
Rat
Rat, E17
Hayakawa, K. , Esposito, E. , Wang, X. , Terasaki, Y. , Liu, Y. , Xing, C. , Ji. X. and Lo, E.
Transfer of Mitochondria from Astrocytes to Neurons after Stroke. ,
Nature
 535 , 551-5 , 2016
Cells
Neurons
Enzymes
PDS kit : per instructions
Medium
DMEM
Neural
Rat
Rat, 6-8 week
Mothe, A. and Tator, C.
Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord. ,
J Vis Exp
 , e52732 , 2015
Cells
Spinal cord neural progenitor
Enzymes
PDS kit : with modifications
Medium
EBSS
Neural
Rat
Rat, embryonic and neonatal
Rheaume, C. , Cai, B. , Wang, J. , Fernandez-Salas, E. , Aoki, K. , Francis, J. and Broide, R.
A Highly Specific Monoclonal Antibody for Botulinum Neurotoxin Type A-Cleaved SNAP25. ,
Toxins
 7 , 2354-70 , 2015
Cells
Cortical neurons, DRG
Enzymes
PDS kit : per instructions
Medium
Neurobasal
Neural
Rat
Rat, SD, embryonic
Loktev, A. and Jackson, P.
Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia. ,
Cell Rep
 5 , 1316-29 , 2013
Cells
Hypothalamic neuronal
Enzymes
PDS kit : per instructions
Medium
Neurobasal A
Neural
Rat
Rat, SD, 7 day
Tanaka, S. , Shaikh, I. , Chiocca, E. and Saeki, Y.
The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells During Postnatal Development. ,
PLoS ONE
 4 , e5922 , 2009
Cells
Cerebellar granule neurons
Enzymes
PDS kit : per instructions
Medium
PBS
Neural
Rat
Rat, Wistar, 4 day
Obradovic Darja, Gronemeyer Hinrich, Lutz Beat, Rein Theo.
Cross-talk of vitamin D and glucocorticoids in hippocampal cells ,
J Neurochem
 96 , 500-9 , 2006
Cells
Hippocampal neurons
Enzymes
PDS kit : per instructions
Medium
Neurobasal A
Neural
Rat
Rat, SD, neonatal
Lacroix-Fralish, M. , Tawfik, V. , Nutile-McMenemy, N. , Harris, B. and Deleo, J.
Differential Regulation of Neuregulin 1 Expression by Progesterone in Astrocytes and Neurons. ,
Neuron Glia Biol
 2 , 227 , 2006
Cells
astrocytes
Enzymes
PDS kit : per instructions
Medium
DMEM
Neural
Rat
Rat, 2 month
Mothe, A. , Kulbatski, I. , Van Bendegem, R. , Lee, L. , Kobayashi, E. , Keating, A. and Tator, C.
Analysis of Green Fluorescent Protein Expression in Transgenic Rats for Tracking Transplanted Neural Stem/Progenitor Cells ,
J Histochem Cytochem
 53(10) , 1215 , 2005
Cells
Spinal cord progenitor cells
Hybrid toxins
Enzymes
PDS kit : see reference
Medium
Neurobasal A
Neural
Rat
Rat, SD, E19
Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, Norman MH, Wild KD, Bannon AW, Louis JC, Treanor JJ.
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties ,
J Pharmacol Exp Ther
 313 , 474 , 2005
Cells
Dorsal root ganglia
Enzymes
PDS kit : per instructions
Medium
MEM/Ham's F12
Neural
Rat
Rat, fetal
Lovshin JA, Huang Q, Seaberg R, Brubaker PL, Drucker DJ.
Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells ,
Endocrinology
 145 , 3495 , 2004
Cells
Brainstem and cortical neurons
Enzymes
PDS kit : per instructions
Medium
DMEM
Neural
Rat
Rat, SD, male, 270-330 g
Lin CR, Wu PC, Shih HC, Cheng JT, Lu CY, Chou AK, Yang LC.
Intrathecal spinal progenitor cell transplantation for the treatment of neuropathic pain ,
Cell Transplant
 11 , 17 , 2002
Cells
Spinal progenitor cells
Enzymes
PDS kit : with modifications
Medium
Neurobasal medium
Neural
Rat
Rat, embryonic 18-19 day
Mabuchi T, Kitagawa K, Kuwabara K, Takasawa K, Ohtsuki T, Xia Z, Storm D, Yanagihara T, Hori M, Matsumoto M.
Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo ,
J Neurosci
 21 , 9204-13 , 2001
Cells
Hippocampal neurons
Enzymes
PDS kit : see reference
Medium
DMEM
Stem
Rat
Rat, 6-8 week
Mothe, A. and Tator, C.
Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord. ,
J Vis Exp
 , e52732 , 2015
Cells
Spinal cord neural progenitor
Enzymes
PDS kit : with modifications
Medium
EBSS
Stem
Rat
Rat, 2 month
Mothe, A. , Kulbatski, I. , Van Bendegem, R. , Lee, L. , Kobayashi, E. , Keating, A. and Tator, C.
Analysis of Green Fluorescent Protein Expression in Transgenic Rats for Tracking Transplanted Neural Stem/Progenitor Cells ,
J Histochem Cytochem
 53(10) , 1215 , 2005
Cells
Spinal cord progenitor cells
Hybrid toxins
Enzymes
PDS kit : see reference
Medium
Neurobasal A

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.