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Tissue References Search Tool

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Heart
Mouse
Mouse, neonatal 2-4 day
Bettahi, I,, Marker, C. , Roman, M. and Wickman, K.
Contribution of the Kir3.1 Subunit to the Muscarinic-gated Atrial Potassium Channel IKACh ,
J Biol Chem
 277 , 48282 , 2002
Cells
Atrial myocytes
Enzymes
NCIS kit : with modifications see reference
Medium
L-15
Heart
Mouse
Mouse, 1 day
Lader, A. , Kwiatkowski, D. and Cantiello, H.
Role of Gelsolin in the Actin Filament Regulation of Cardiac L-type Calcium Channels ,
Am J Physiol
 277 , C1277 , 1999
Cells
Cardiomyocytes
Enzymes
NCIS kit : with modifications see reference
Medium
L-15
Heart
Mouse
Mouse, 1 day
Lader, A. , Xiao, Y. , Ishikawa, Y. , Cui, Y. , Vatner, D. , Vatner, S. , Homcy, C. and Cantiello, H.
Cardiac Gsalpha Overexpression Enhances L-type Calcium Channels Through an Adenylyl Cyclase Independent Pathway ,
Proc Natl Acad Sci U S A
 95 , 9669 , 1998
Cells
Cardiomyocytes
Enzymes
NCIS kit : with modifications see reference
Medium
L-15
Heart
Mouse
Mouse, 6-9 or 21-41 day
Valenzuela, D. , Han, X. , Mende, U. , Fankhauser, C. , Mashimo, H. , Huang, P. , Pfeffer, J. , Neer, E. and Fishman, M.
G alpha(o) is Necessary for Muscarinic Regulation of Ca2+ Channels in Mouse Heart ,
Proc Natl Acad Sci U S A
 94(5) , 1727 , 1997
Cells
Ventricular and atrial myocytes
Enzymes
Collagenase Type 2 : 95 u/ml
Hyaluronidase : 172.5 u/ml
Trypsin : 0.002%
Medium
DMEM/Tyrodes
Heart
Rabbit
Rabbit, New Zealand, 2.3-2.9 kg
Farkas, A. , Acsai, K. , Nagy, N. , Toth, A. , Fulop, F. , Seprenyi, G. , Birinyi, P. , Nanasi, P. , Forster, T. , Csanady, M. , Papp, J. , Varrro, A. and Farkas, A.
Na(+)/Ca(2+) Exchanger Inhibition Exerts a Positive Inotropic Effect in the Rat Heart, but Fails to Influence the Contractility of the Rabbit Heart. ,
Br J Pharmacol
 154 , 93 , 2008
Cells
Cardiomyocytes
Enzymes
Hyaluronidase : see reference
Protease : see reference
Medium
Krebs-Henseleit
Heart
Rabbit
Rabbit, New Zealand, white, male, 2-3 kg
Buxton, I. and Brunton, L.
Compartments of Cyclic AMP and Protein Kinase in Mammalian Cardiomyocytes ,
J Biol Chem
 258 (17) , 10233 , 1983
Cells
Cardiomyocytes
Enzymes
Hyaluronidase : 0.5%
Medium
Eagle's MEM
Heart
Rabbit
Rabbit, adult, 2 kg
Dani, A. , Cittadini, A. , Flamini, G. , Festuccia, G. and Terranova, T.
Preparation and Some Properties of Isolated Beating Myocytes from Adult Rabbit Heart ,
J Mol Cell Cardiol
 9 , 777 , 1977
Cells
Myocytes
Enzymes
Hyaluronidase : 0.007%
Medium
Kreb's Ringer
Heart
Rat
Rat, 1-2 day
Xie, L. , Pi, X. , Townley-Tilson, WH. , Li, N. , Wehrens, X. , Entman, M. , Taffet, G. , Mishra, A. , Peng, J. , Schisler, J. , Meissner, G. and Patterson, C.
PHD2/3-dependent Hydroxylation Tunes Cardiac Response to β-adrenergic Stress via Phospholamban. ,
J Clin Invest
 125 , 2759-71 , 2015
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
MEM
Heart
Rat
Rat, neonatal
Song, D. , Lee, K. , Ryu, J. , Jeon, H. and Kim, D.
The Molecular Interaction of Heart LIM Protein (HLP) with RyR2 and Caveolin-3 is Essential for Ca(2+)-Induced Ca(2+) Release in the Heart. ,
Biochem Biophys Res Commun
 463 , 975-81 , 2015
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
HBSS
Heart
Rat
Rat, neonatal
Sakurai, T. , Lanahan, A. , Woolls, M. , Li, N. , Tirziu, D. and Murakami, M.
Live Cell Imaging of Primary Rat Neonatal Cardiomyocytes Following Adenoviral and Lentiviral Transduction using Confocal Spinning Disk Microscopy. ,
J Vis Exp
 , e51666 , 2014
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Dittami, G. , Rajguru, S. , Lasher, R. , Hitchcock, R. and Rabbitt, R.
Intracellular Calcium Transients Evoked by Pulsed Infrared Radiation in Neonatal Cardiomyocytes. ,
J Physiol
 589 , 1295-306 , 2011
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, Wistar, male
Brinckmann, M. , Kaschina, E. , Altarche-Xifro, W. , Curato, C. , Timm, M. , Grzesiak, A. , Dong, J. , Kappert, K. , Kintscher, U. , Unger, T. and Li, J.
Estrogen Receptor Alpha Supports Cardiomyocytes Indirectly Through Post-Infarct Cardiac c-kit+ Cells. ,
J Mol Cell Cardiol
 47 , 66 , 2009
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Smith, M. , Huang, Y. and Deshmukh, M.
Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway. ,
PLoS ONE
 4 , e5097 , 2009
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 1-2 day
Kim, M. , Oh, J. , Sakata, S. , Liang, I. , Park, W. , Hajjar, R. and Lebeche, D.
Role of Resistin in Cardiac Contractility and Hypertrophy. ,
J Mol Cell Cardiol
 45 , 270 , 2008
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 200-250 g
Farkas, A. , Acsai, K. , Nagy, N. , Toth, A. , Fulop, F. , Seprenyi, G. , Birinyi, P. , Nanasi, P. , Forster, T. , Csanady, M. , Papp, J. , Varrro, A. and Farkas, A.
Na(+)/Ca(2+) Exchanger Inhibition Exerts a Positive Inotropic Effect in the Rat Heart, but Fails to Influence the Contractility of the Rabbit Heart. ,
Br J Pharmacol
 154 , 93 , 2008
Cells
Cardiomyocytes
Enzymes
Hyaluronidase : see reference
Protease : see reference
Medium
Krebs-Henseleit
Heart
Rat
Rat, neonatal
Robinet, A. , Millart, H. , Oszust, F. , Hornebeck, W. and Bellon, G.
Binding of Elastin Peptides to S-Gal Protects the Heart Against Ischemia/Reperfusion Injury by Triggering the RISK Pathway. ,
FASEB J
 21 , 1968 , 2007
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, male
Stagg Mark A, Coppen Steven R, Suzuki Ken, Varela-Carver Anabel, Lee Joon, Brand Nigel J, Fukushima Satsuki, Yacoub Magdi H, Terracciano Cesare M.
Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation ,
FASEB J
 20 , 744-6 , 2006
Cells
Ventricular myocytes
Enzymes
Collagenase : 0.13%
Hyaluronidase : 0.06%
Medium
DMEM
Heart
Rat
Rat, Wistar, neonatal
Butler, T. , Au, C. , Yang, B. , Egan, J. , Tan, Y. , Hardeman, E. , North, K. , Verkman, A. and Winlaw, D.
Cardiac Aquaporin Expression in Humans, Rats, and Mice. ,
Am J Physiol Heart Circ Physiol
 291 , H705 , 2006
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 300-350 g
Niederbichler Andreas D, Hoesel Laszlo M, Westfall Margaret V, Gao Hongwei, Ipaktchi Kyros R, Sun Lei, Zetoune Firas S, Su Grace L, Arbabi Saman, Sarma J Vidya, Wang StewartC, Hemmila MarkR, Ward PeterA.
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction ,
J Exp Med
 203 , 53-61 , 2006
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, 1-2 day
Pedram, A. , Razandi, M. , Aitkenhead, M. and Levin, E
Estrogen Inhibits Cardiomyocyte Hypertrophy in vitro. Antagonism of Calcineurin-related Hypertrophy through Induction of MCIP1 ,
J Biol Chem
 280 , 26339 , 2005
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM/F-12
Heart
Rat
Rat, Wistar, 1-3 day
Castillo, A. , Ruzmetov, N. , Harvey, K. , Stillwell, W. , Zaloga, G. and Siddiqui, R.
Docosahexaenoic Acid Inhibits Protein Kinase C Translocation/Activation and Cardiac Hypertrophy in Rat Cardiomyocytes. ,
J Mol Genet Med
 1 , 18 , 2005
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 1-2 day
Muller-Bore, B. , Cascio, W. , Anderson, P. , Snowwaert, J. , Frye, J. , Desai, N. , Esch, G. , Brackham, J. , Bagnell, C. , Coleman, W. , Grisham, J. and Malouf, N.
Adult-derived Liver Stem Cells Acquire a Cardiomyocyte Structural and Functional Phenotype ex vivo ,
Am J Pathol
 165 , 135 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat,1-2 day
Natarajan AR, Rong Q, Katchman AN. and Ebert SN.
Intrinsic cardiac catecholamines help maintain beating activity in neonatal rat cardiomyocyte cultures ,
Pediatr Res
 56 , 411 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM
Heart
Rat
Rat, 1 day
Chen, Z. , Ge, Y. and Kang J.
Down-regulation of the M6P/IGF-II Receptor Increases Cell Proliferation and Reduces Apoptosis in Neonatal Rat Cardiac Myocytes ,
BMC Cell Biol
 5 , 15 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
F-10
Heart
Rat
Rat, neonatal
Li TS, Ito H, Kajiwara K. and Hamano K.
Long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and CD40 blockade ,
Circulation
 108 , 1760 , 2003
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, 50 g
Aberle II NS. and Ren J.
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy ,
Biol Proced Online
 5 , 1 , 2003
Cells
Ventricular myocytes
Enzymes
Collagenase : 223 u/ml
Hyaluronidase : 0.01%
Trypsin : 0.002%
Medium
Medium 199
Heart
Rat
Rat, adult, 220-280g
Gordon Jennifer M, Dusting Gregory J, Woodman Owen L, Ritchie Rebecca H.
Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes ,
Am J Physiol Heart Circ Physiol
 284 , H330-6 , 2003
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 178 u/ml
Hyaluronidase : 0.01%
Medium
Krebs-Henseleit, CF
Heart
Rat
Rat, 1 day
Yang Y, Liao H, Ke Q, Cai J, Xiao YF. and Morgan JP
Enhancement of nitric oxide production by methylecgonidine in cultured neonatal rat cardiomyocytes ,
Br J Pharmacol
 135 , 188 , 2002
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, pregnant female
DeAlmeida, A. , Mustin, D. , Forman, M. , Brower, G. , Janicki, J. and Carver, W.
Effects of mast cells on the behavior of isolated heart fibroblasts: modulation of collagen remodeling and gene expression ,
J Cell Physiol
 191 , 51 , 2002
Cells
Peritoneal mast
Enzymes
Hyaluronidase : 100 u/ml
Medium
DMEM (see reference)
Heart
Rat
Rat, SD, newborn
Rahman A, Alam M, Rao S, Cai L, Clark LT, Shafiq S. and Siddiqui MA
Differential effects of doxorubicin on atrial natriuretic peptide expression in vivo and in vitro ,
Biol Res
 34(3-4) , 195 , 2001
Cells
Cardiac myocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, adult
Ren J. and Wold LE.
Measurement of Cardiac Mechanical Function in Isolated Ventricular Myocytes from Rats and Mice by Computerized Video-Based Imaging ,
Biol Proced Online
 3 , 43 , 2001
Cells
Ventricular myocytes
Enzymes
Collagenase : 223 u/ml
Hyaluronidase : 0.01%
Trypsin : 0.002%
Medium
Tyrode solution
Heart
Rat
Rat, neonatal
Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K, Yu KT, Jaye M, Ivashchenko Y.
Hypoxia induces the expression of the pro-apoptotic gene BNIP3 ,
Cell Death Differ
 8 , 367-76 , 2001
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM/M199
Heart
Rat
Rat, wistar, 2 day
Cowan DB, Poutias DN, Del Nido PJ. and McGowan FX Jr
CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin ,
Am J Physiol Heart Circ Physiol
 279 , H619 , 2000
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM-F12
Heart
Rat
Rat, neonatal
Webster DR. and Patrick DL.
Beating rate of isolated neonatal cardiomyocytes is regulated by the stable microtubule subset ,
Am J Physiol Heart Circ Physiol
 278 , H1653 , 2000
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, 1-2 day
Matsui, T. , Li, Ling, Del Monte, F. , Fukui, Y. , Franke, T. , Hajjar, R. and Rosenzweig, A.
Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro ,
Circulation
 100 , 2373-9 , 1999
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
RPMI
Heart
Rat
Rat, SD, 1 day
Wagner DR, Combes A, McTiernan C, Sanders VJ, Lemster B, Feldman AM.
Adenosine inhibits lipopolysaccharide-induced cardiac expression of tumor necrosis factor-alpha ,
Circ Res
 82 , 47-56 , 1998
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM/F-12

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.