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Tissue References Search Tool

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Heart
Canine
Canine
Harleton, E. , Besana, A. , Comas, G. , Danilo, P. , Rosen, T. , Argenziano, M. , Rosen, M. , Robinson, R. and Feinmark, S.
Ability to Induce Atrial Fibrillation in the Peri-Operative Period is Associated with Phosphorylation-Dependent Inhibition of TWIK Protein-Related Acid-Sensitive Potassium Channel 1 (TASK-1). ,
J Biol Chem
 288 , 2829-38 , 2013
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 60 u/ml
Protease XIV : 0.5 u/ml
Medium
See reference
Heart
Fish
Zebrafish
Fowler, E. , Wang, N. , Hezzell, M. , Chanoit, G. , Hancox, J. and Cannell, M.
Arrhythmogenic Late Ca2+ Sparks in Failing Heart Cells and Their Control by Action Potential Configuration ,
Proc Natl Acad Sci U S A
 117 , 2687-2692 , 2020
Cells
Cardiac Myocytes
Enzymes
Trypsin : 0.08%
Protease XIV : 0.005%
Collagenase Type 1 : 0.1-0.2%
Medium
HEPES
Heart
Human
Human
Todor Anastassia, Sharov Victor G, Tanhehco Elaine J, Silverman Norman, Bernabei Alvise, Sabbah Hani N.
Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes ,
Am J Physiol Heart Circ Physiol
 283 , H990-5 , 2002
Cells
Cardiomyocytes
Enzymes
Protease XIV : 0.013%
Medium
HEPES solution
Heart
Mouse
Mouse, male, 12-18 week
Jian, Z, Chen, Y, Shimkunas, R, Jian, Y, Jaradeh, M, Chavez, K, Chiamvimonvat, N, Tardiff, J, Izu, L, Ross, R. and Chen-Izu, Y
In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. ,
PLoS ONE
 11 , e0160605 , 2016
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 300 u/ml
Protease XIV : 0.004%
Medium
Perfusion solution (see reference)
Heart
Mouse

Mouse, 8-12 week

Ackers-Johnson, M. , Li, P. , Holmes, A. , O'Brien, S. , Pavlovic, D. and Foo, R.
A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse Heart. ,
Circ Res
 119 , 909-20 , 2016
Cells
Cardiomyocytes
Enzymes
Protease XIV : 0.005%
Medium
Perfusion buffer (see reference)
Heart
Mouse
Mouse, adult, 9-13 week
Kabaeva, Z. , Zhao, M. and Michele, D.
Blebbistatin Extends Culture Life of Adult Mouse Cardiac Myocytes and Allows Efficient and Stable Transgene Expression. ,
Am J Physiol Heart Circ Physiol
 294 , H1667-74 , 2008
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 620 u/ml
Protease XIV : 0.104 u/ml
Medium
Myocyte buffer see reference
Heart
Mouse
Mouse, adult, 6-12 week
Shioya, T.
A Simple Technique for Isolating Healthy Heart Cells from Mouse Models. ,
J Physiol Sci
 57 , 327-35 , 2007
Cells
Cardiomyocytes
Enzymes
Trypsin : 0.006%
Protease XIV : 0.006%
Medium
see reference
Heart
Mouse
Mouse, 1 day
Potts, Malia B. , Vaughn, Allyson E. , McDonough, Holly, Patterson, Cam. and Deshmukh, Mohanish
Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP ,
J Cell Biol
 171 , 925 , 2005
Cells
Cardiomyoctes
Enzymes
NCIS kit : per instructions
Medium
EBSS
Heart
Mouse
Mouse, neonatal 2-4 day
Bettahi, I,, Marker, C. , Roman, M. and Wickman, K.
Contribution of the Kir3.1 Subunit to the Muscarinic-gated Atrial Potassium Channel IKACh ,
J Biol Chem
 277 , 48282 , 2002
Cells
Atrial myocytes
Enzymes
NCIS kit : with modifications see reference
Medium
L-15
Heart
Mouse
Mouse, 2-4 mo
Zhou YY, Wang SQ, Zhu WZ, Chruscinski A, Kobilka BK, Ziman B, Wang S, Lakatta EG, Cheng H, Xiao RP.
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology ,
Am J Physiol Heart Circ Physiol
 279 , H429-36 , 2000
Cells
Ventricular myocytes
Enzymes
Protease XIV : 0.002%
Medium
MEM
Heart
Mouse
Mouse, 1 day
Lader, A. , Kwiatkowski, D. and Cantiello, H.
Role of Gelsolin in the Actin Filament Regulation of Cardiac L-type Calcium Channels ,
Am J Physiol
 277 , C1277 , 1999
Cells
Cardiomyocytes
Enzymes
NCIS kit : with modifications see reference
Medium
L-15
Heart
Mouse
Mouse, 1 day
Lader, A. , Xiao, Y. , Ishikawa, Y. , Cui, Y. , Vatner, D. , Vatner, S. , Homcy, C. and Cantiello, H.
Cardiac Gsalpha Overexpression Enhances L-type Calcium Channels Through an Adenylyl Cyclase Independent Pathway ,
Proc Natl Acad Sci U S A
 95 , 9669 , 1998
Cells
Cardiomyocytes
Enzymes
NCIS kit : with modifications see reference
Medium
L-15
Heart
Ovine
Ovine
Voigt, N. , Pearman, C. , Dobrev, D. and Dibb, K.
Methods for Isolating Atrial Cells from Large Mammals and Humans. ,
J Mol Cell Cardiol
 86 , 187-98 , 2015
Cells
Atrial myocytes
Enzymes
Protease XIV : 0.006%
Medium
Tyrode's solution
Heart
Rabbit
Rabbit, New Zealand, 3-3.5 kg
Fowler, E. , Wang, N. , Hezzell, M. , Chanoit, G. , Hancox, J. and Cannell, M.
Arrhythmogenic Late Ca2+ Sparks in Failing Heart Cells and Their Control by Action Potential Configuration ,
Proc Natl Acad Sci U S A
 117 , 2687-2692 , 2020
Cells
Cardiac Myocytes
Enzymes
Trypsin : 0.08%
Protease XIV : 0.005%
Collagenase Type 1 : 0.1-0.2%
Medium
HEPES
Heart
Rat
Rat, 1-2 day
Xie, L. , Pi, X. , Townley-Tilson, WH. , Li, N. , Wehrens, X. , Entman, M. , Taffet, G. , Mishra, A. , Peng, J. , Schisler, J. , Meissner, G. and Patterson, C.
PHD2/3-dependent Hydroxylation Tunes Cardiac Response to β-adrenergic Stress via Phospholamban. ,
J Clin Invest
 125 , 2759-71 , 2015
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
MEM
Heart
Rat
Rat, neonatal
Song, D. , Lee, K. , Ryu, J. , Jeon, H. and Kim, D.
The Molecular Interaction of Heart LIM Protein (HLP) with RyR2 and Caveolin-3 is Essential for Ca(2+)-Induced Ca(2+) Release in the Heart. ,
Biochem Biophys Res Commun
 463 , 975-81 , 2015
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
HBSS
Heart
Rat
Rat, neonatal
Sakurai, T. , Lanahan, A. , Woolls, M. , Li, N. , Tirziu, D. and Murakami, M.
Live Cell Imaging of Primary Rat Neonatal Cardiomyocytes Following Adenoviral and Lentiviral Transduction using Confocal Spinning Disk Microscopy. ,
J Vis Exp
 , e51666 , 2014
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Dittami, G. , Rajguru, S. , Lasher, R. , Hitchcock, R. and Rabbitt, R.
Intracellular Calcium Transients Evoked by Pulsed Infrared Radiation in Neonatal Cardiomyocytes. ,
J Physiol
 589 , 1295-306 , 2011
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, Wistar, male
Brinckmann, M. , Kaschina, E. , Altarche-Xifro, W. , Curato, C. , Timm, M. , Grzesiak, A. , Dong, J. , Kappert, K. , Kintscher, U. , Unger, T. and Li, J.
Estrogen Receptor Alpha Supports Cardiomyocytes Indirectly Through Post-Infarct Cardiac c-kit+ Cells. ,
J Mol Cell Cardiol
 47 , 66 , 2009
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Smith, M. , Huang, Y. and Deshmukh, M.
Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway. ,
PLoS ONE
 4 , e5097 , 2009
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, adult
Xu, X. and Colecraft, H.
Primary Culture of Adult Rat Heart Myocytes. ,
J Vis Exp
 28 , 1308 , 2009
Cells
Myocytes
Enzymes
Protease XIV : 0.02%
Medium
Media 199
Heart
Rat
Rat, SD, 1-2 day
Kim, M. , Oh, J. , Sakata, S. , Liang, I. , Park, W. , Hajjar, R. and Lebeche, D.
Role of Resistin in Cardiac Contractility and Hypertrophy. ,
J Mol Cell Cardiol
 45 , 270 , 2008
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Robinet, A. , Millart, H. , Oszust, F. , Hornebeck, W. and Bellon, G.
Binding of Elastin Peptides to S-Gal Protects the Heart Against Ischemia/Reperfusion Injury by Triggering the RISK Pathway. ,
FASEB J
 21 , 1968 , 2007
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, Wistar, neonatal
Butler, T. , Au, C. , Yang, B. , Egan, J. , Tan, Y. , Hardeman, E. , North, K. , Verkman, A. and Winlaw, D.
Cardiac Aquaporin Expression in Humans, Rats, and Mice. ,
Am J Physiol Heart Circ Physiol
 291 , H705 , 2006
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, 1-2 day
Pedram, A. , Razandi, M. , Aitkenhead, M. and Levin, E
Estrogen Inhibits Cardiomyocyte Hypertrophy in vitro. Antagonism of Calcineurin-related Hypertrophy through Induction of MCIP1 ,
J Biol Chem
 280 , 26339 , 2005
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM/F-12
Heart
Rat
Rat, Wistar, 1-3 day
Castillo, A. , Ruzmetov, N. , Harvey, K. , Stillwell, W. , Zaloga, G. and Siddiqui, R.
Docosahexaenoic Acid Inhibits Protein Kinase C Translocation/Activation and Cardiac Hypertrophy in Rat Cardiomyocytes. ,
J Mol Genet Med
 1 , 18 , 2005
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 1-2 day
Muller-Bore, B. , Cascio, W. , Anderson, P. , Snowwaert, J. , Frye, J. , Desai, N. , Esch, G. , Brackham, J. , Bagnell, C. , Coleman, W. , Grisham, J. and Malouf, N.
Adult-derived Liver Stem Cells Acquire a Cardiomyocyte Structural and Functional Phenotype ex vivo ,
Am J Pathol
 165 , 135 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat,1-2 day
Natarajan AR, Rong Q, Katchman AN. and Ebert SN.
Intrinsic cardiac catecholamines help maintain beating activity in neonatal rat cardiomyocyte cultures ,
Pediatr Res
 56 , 411 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM
Heart
Rat
Rat, 1 day
Chen, Z. , Ge, Y. and Kang J.
Down-regulation of the M6P/IGF-II Receptor Increases Cell Proliferation and Reduces Apoptosis in Neonatal Rat Cardiac Myocytes ,
BMC Cell Biol
 5 , 15 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
F-10
Heart
Rat
Rat, neonatal
Li TS, Ito H, Kajiwara K. and Hamano K.
Long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and CD40 blockade ,
Circulation
 108 , 1760 , 2003
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, 1 day
Yang Y, Liao H, Ke Q, Cai J, Xiao YF. and Morgan JP
Enhancement of nitric oxide production by methylecgonidine in cultured neonatal rat cardiomyocytes ,
Br J Pharmacol
 135 , 188 , 2002
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, newborn
Rahman A, Alam M, Rao S, Cai L, Clark LT, Shafiq S. and Siddiqui MA
Differential effects of doxorubicin on atrial natriuretic peptide expression in vivo and in vitro ,
Biol Res
 34(3-4) , 195 , 2001
Cells
Cardiac myocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K, Yu KT, Jaye M, Ivashchenko Y.
Hypoxia induces the expression of the pro-apoptotic gene BNIP3 ,
Cell Death Differ
 8 , 367-76 , 2001
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM/M199
Heart
Rat
Rat, wistar, 2 day
Cowan DB, Poutias DN, Del Nido PJ. and McGowan FX Jr
CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin ,
Am J Physiol Heart Circ Physiol
 279 , H619 , 2000
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM-F12
Heart
Rat
Rat, neonatal
Webster DR. and Patrick DL.
Beating rate of isolated neonatal cardiomyocytes is regulated by the stable microtubule subset ,
Am J Physiol Heart Circ Physiol
 278 , H1653 , 2000
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, 1-2 day
Matsui, T. , Li, Ling, Del Monte, F. , Fukui, Y. , Franke, T. , Hajjar, R. and Rosenzweig, A.
Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro ,
Circulation
 100 , 2373-9 , 1999
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
RPMI

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.