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Heart
Rat

Rat, 1-2 day

Yang, M. , Abudureyimu, M. , Wang, X. , Zhou, Y. , Zhang, Y. and Ren, J.
PHB2 ameliorates Doxorubicin-induced cardiomyopathy through interaction with NDUFV2 and restoration of mitochondrial complex I function. , Redox Biol Vol. 65 , 102812 , 2023
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, adult
Zhang, Y. , Wang, Y. , Yanni, J. , Qureshi, M. , Logantha, S. , Kassab, S. , Boyett, M. , Gardiner, N. , Sun, H. , Howarth, F. and Dobrzynski, H.
Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart. ,
Front Physiol
 10 , 826 , 2019
Cells
Sinoatrial nodal
Enzymes
Collagenase Type 4 : 220 u/ml
Elastase : 1.4 u/ml
Protease : 0.45 u/ml
Medium
Tyrode solution
Heart
Rat
Rat, adult
Savi, M. , Bocchi, L. , Mena, P. , Dall'Asta, M. , Crozier, A. , Brighenti, F. , Stilli, D. and Del Rio, D.
In vivo Administration of Urolithin A and B Prevents the Occurrence of Cardiac Dysfunction in Streptozotocin-induced Diabetic Rats. ,
Cardiovasc Diabetol
 16 , 80 , 2017
Cells
Cardiomyocytes
Enzymes
Protease Type XIV : 0.01%
Medium
Tyrode solution
Heart
Rat
Rat, SD, 2 day
Abdul-Ghani, M. , Suen, C. , Jiang, B. , Deng, Y. , Weldrick, J. , Putinski, C. , Brunette, S. , Fernando, P. , Lee, T. , Flynn, P. , Leenen, F. , Burgon, P. Stewart, D. and Megeney, L.
Cardiotrophin 1 Stimulates Beneficial Myogenic and Vascular Remodeling of the Heart. ,
Cell Res
 27 , 1195-1215 , 2017
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 200 u/ml
Medium
DMEM
Heart
Rat
Rat, 250 g
Stoppel, W. , Gao, A. , Greaney, A. , Partlow, B. , Bretherton, R. , Kaplan, D. and Black, L
Elastic, Silk-Cardiac Extracellular Matrix Hydrogels Exhibit Time-Dependent Stiffening that Modulates Cardiac Fibroblast Response. ,
J Biomed Mater Res A
 104 , 3058 , 2016
Cells
Fibroblasts
Enzymes
Collagenase Type 2 : 300 u/ml
Medium
DMEM
Heart
Rat
Rat, SD, 8-10 week
Lee, J. , Ha, J. and Leem, C.
A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca(2+) Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat. ,
Korean J Physiol Pharmacol
 19 , 373-82 , 2015
Cells
Ventricular myocytes
Enzymes
Collagenase : 0.08%
Pronase : 0.004%
Medium
Tyrode's Solution
Heart
Rat
Rat, Wistar, 250-350g
Calderon-Sachez, E. , Domi­nguez-Rodriguez, A. , Lopez-Haldon, J. , Jimenez-Navarro, M. , Gomez, A. , Smani, T. and Ordonez, A.
Cardioprotective Effect of Ranolazine in the Process of Ischemia-reperfusion in Adult Rat Cardiomyocytes. ,
Rev Esp Cardiol (Engl Ed)
 , 2015
Cells
Ventricular myocytes
Enzymes
Collagenase Type 2 : 251 u/ml
Medium
Tyrode solution
Heart
Rat
Rat, SD, 2-3 day
Fang, R, Qiao, S. , Liu, Y. , Meng, Q. , Chen, X. , Song, B. , Hou, X. and Tian, W.
Sustained Co-Delivery of BIO and IGF-1 by a Novel Hybrid Hydrogel System to Stimulate Endogenous Cardiac Repair in Myocardial Infarcted Rat Hearts. ,
Int J Nanomedicine
 10 , 4691-703 , 2015
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, SD
Horne, T. , VandeKopple, M. , Sauls, K. , Koenig, S. , Anstine, L. , Garg, V. , Norris, R. and Lincoln, J.
Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and Disease ,
J Cardiovasc Dev Dis
 2 , 214 , 2015
Cells
Valve interstitial cells
Enzymes
Collagenase Type 2 : 600 u/ml
Medium
DMEM
Heart
Rat
Rat, SD, 1 day
Clark, A. and Naya, F.
MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2. ,
J Biol Chem
 290 , 23162-72 , 2015
Cells
Cardiomyocytes
Enzymes
Trypsin : 0.025%
Medium
HBSS
Heart
Rat
Rat, Wistar, 200g
Miller, L. , Greensmith, D. , Sankaranarayanan, R. , O'Neill, S. and Eisner D.
The Effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on Intracellular Ca2+ Handling in Rat Ventricular Myocytes. ,
Cell Calcium
 58 , 208-14 , 2015
Cells
Ventricular myocytes
Enzymes
Collagenase Type 2 : 95 u/ml
Protease : 0.1 u/ml
Medium
HEPES
Heart
Rat
Rat, SD, 3-4 month
Liu, L. , Wang, Y. , Cao, Z. , Wang, M. , Liu, X. , Gao, T. , Hu, Q. , Yuan, W. and Lin, L.
Up-regulated TLR4 in Cardiomyocytes Exacerbates Heart Failure after Long-Term Myocardial Infarction. ,
J Cell Mol Med
 19 , 2728 , 2015
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, neonatal
Zhang, B. , Montgomery, M. , Davenport-Huyer, L. , Korolj, A. and Radisic, M.
Platform Technology for Scalable Assembly of Instantaneously Functional Mosaic Tissues. ,
Sci. Adv.
 1 , e1500423 , 2015
Cells
Cardiomyocytes
Enzymes
Trypsin : 0.06%
Collagenase Type 2 : 220 u/ml
Medium
HBSS
Heart
Rat
Rat, SD, 1-2 day
Rutering, J. , Ilmer, M. , Recio, A. , Coleman, M. , Vykoukal, J. and Alt, E.
Improved Method for Isolation of Neonatal Rat Cardiomyocytes with Increased Yield of C-Kit+ Cardiac Progenitor Cells. ,
J Stem Cell Res Ther
 5 , 1-8 , 2015
Cells
Cardiomyocytes
Enzymes
Medium
DMEM/F-12
Heart
Rat
Rat, adult, 300-370 g
Chouchani, E. , Pell, V. , Gaude, E. , Aksentijevic, D. , Sundier, S. , Robb, E. , Logan, A. , Nadtochiy, S. , Ord, E. , Smith, A. , Eyassu, F. , Shirley, R. , Hu, C. , Dare, A. , James, A. and Rogatti, S.
Ischaemic Accumulation of Succinate Controls Reperfusion Injury Through Mitochondrial ROS. ,
Nature
 515 , 431-435 , 2014
Cells
Cardiomyocytes
Enzymes
Medium
KH buffer
Heart
Rat
Rat
Hennessey, J. , Wei, E. and Pitt, G.
Fibroblast Growth Factor Homologous Factors Modulate Cardiac Calcium Channels. ,
Circ Res
 113 , 381-8 , 2013
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 150 u/ml
Medium
MEM
Heart
Rat
Rat, Wistar, 175-200g
Eckerle, L. , Felix, S. and Herda, L.
Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes. ,
J Vis Exp
 73 , e4237 , 2013
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 150 u/ml
Medium
see reference
Heart
Rat
Rat, SD, 1-2 day
Zhang, B. , Green, J. , Murthy, S. and Radisic, M.
Label-Free Enrichment of Functional Cardiomyocytes using Microfluidic Deterministic Lateral Flow Displacement. ,
PLoS ONE
 7 , e37619 , 2012
Cells
Cardiomyocytes
Enzymes
Trypsin : 0.06%
Collagenase Type 2 : 220 u/ml
Medium
DMEM
Heart
Rat
Rat, adult
Karakikes, I. , Hadri, L. , Rapti, K. , Ladage, D. , Ishikawa, K. , Tilemann, L. , Yi, G. , Morel, C. , Gwathmey, J. , Zsebo, K. , Weber, T. , Kawase, Y. and Hajjar, R.
Concomitant Intravenous Nitroglycerin with Intracoronary Delivery of AAV1.SERCA2a Enhances Gene Transfer in Porcine Hearts. ,
Mol Ther
 20 , 565 , 2012
Cells
Ventricular myocytes
Enzymes
Medium
Medium 199
Heart
Rat
Rat, SD, male
Mellor, K. , Bell, J. , Wendt, I. , Davidoff, A. , Ritchie, R. and Delbridge, L.
Fructose Modulates Cardiomyocyte Excitation-Contraction Coupling and Ca Handling In Vitro. ,
PLoS ONE
 6 , e25204 , 2011
Cells
Cardiomyocytes
Enzymes
Medium
Krebs
Heart
Rat
Rat, 3 day
Ye, K. , Sullivan, K. and Black, L.
Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering. ,
J Vis Exp
 55 , 3251 , 2011
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 300 u/ml
Medium
PBS
Heart
Rat
Rat, neonatal
Guan, X. , Delo, D. , Atala, A. and Soker, S.
In Vitro Cardiomyogenic Potential of Human Amniotic Fluid Stem Cells. ,
J Tissue Eng Regen Med
 5 , 220 , 2011
Cells
Cardiomyocytes
Enzymes
Trypsin : 0.07%
Medium
DMEM/M199
Heart
Rat
Rat, adult
Louch, W. , Sheehan, K. and Wolska, B.
Methods in Cardiomyocyte Isolation, Culture, and Gene Transfer. ,
J Mol Cell Cardiol
 51 , 288-98 , 2011
Cells
Cardiomyocytes
Enzymes
Medium
see reference
Heart
Rat
Rat, adult
Xu, X. and Colecraft, H.
Primary Culture of Adult Rat Heart Myocytes. ,
J Vis Exp
 28 , 1308 , 2009
Cells
Myocytes
Enzymes
Protease XIV : 0.02%
Medium
Media 199
Heart
Rat
Rat, SD, 2 day
Jang, J. , Ku, S. , Kim, J. , Choi, K. , Kim, Y. , Kim, H. , Oh, S. , Lee, E. , Cho, H. , Song, Y. , Lee, S. , Lee, S. , Suh, C. , Kim, S. , Moon, S. and Choi, Y.
Notch Inhibition Promotes Human Embryonic Stem Cell-Derived Cardiac Mesoderm Differentiation. ,
Stem Cells
 26 , 2782 , 2008
Cells
Cardiomyocytes
Enzymes
Medium
DMEM/F-12
Heart
Rat
Rat, SD, male, 225-250g
Kubli, D. , Quinsay, M. , Huang, C. , Lee, Y. and Gustafsson, A.
Bnip3 Functions as a Mitochondrial Sensor of Oxidative Stress During Myocardial Ischemia and Reperfusion. ,
Am J Physiol Heart Circ Physiol
 295 , H2025 , 2008
Cells
Cardiomyocytes
Enzymes
Medium
J-MEM
Heart
Rat
Rat, SD, 200-250 g
Farkas, A. , Acsai, K. , Nagy, N. , Toth, A. , Fulop, F. , Seprenyi, G. , Birinyi, P. , Nanasi, P. , Forster, T. , Csanady, M. , Papp, J. , Varrro, A. and Farkas, A.
Na(+)/Ca(2+) Exchanger Inhibition Exerts a Positive Inotropic Effect in the Rat Heart, but Fails to Influence the Contractility of the Rabbit Heart. ,
Br J Pharmacol
 154 , 93 , 2008
Cells
Cardiomyocytes
Enzymes
Hyaluronidase : see reference
Protease : see reference
Medium
Krebs-Henseleit
Heart
Rat
Rat
Jenkins, C. , Milsted, A. , Doane, K. , Meszaros, G. , Toot, J. and Ely, D.
A Cell Culture Model using Rat Coronary Artery Adventitial Fibroblasts to Measure Collagen Production. ,
BMC Cardiovasc Disord
 7 , 13 , 2007
Cells
Ventricular fibroblasts
Enzymes
Trypsin : 0.06%
Collagenase : 100 u/ml
Medium
ADS Buffer:see reference
Heart
Rat
Rat, 2-3 day
LaFramboise, W. , Scalise, D. , Stoodley, P. , Graner, S. , Guthrie, R. , Magovern, J. and Becich, M.
Cardiac Fibroblasts Influence Cardiomyocyte Phenotype in Vitro. ,
Am J Physiol Cell Physiol
 292 , C1799-808 , 2007
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, SD, male
Stagg Mark A, Coppen Steven R, Suzuki Ken, Varela-Carver Anabel, Lee Joon, Brand Nigel J, Fukushima Satsuki, Yacoub Magdi H, Terracciano Cesare M.
Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation ,
FASEB J
 20 , 744-6 , 2006
Cells
Ventricular myocytes
Enzymes
Collagenase : 0.13%
Hyaluronidase : 0.06%
Medium
DMEM
Heart
Rat
Rat, SD, 300-350 g
Niederbichler Andreas D, Hoesel Laszlo M, Westfall Margaret V, Gao Hongwei, Ipaktchi Kyros R, Sun Lei, Zetoune Firas S, Su Grace L, Arbabi Saman, Sarma J Vidya, Wang StewartC, Hemmila MarkR, Ward PeterA.
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction ,
J Exp Med
 203 , 53-61 , 2006
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, SD, 200-250 g
Lu Tong, Ye Dan, Wang Xiaoli, Seubert John M, Graves Joan P, Bradbury J Alyce, Zeldin Darryl C, Lee Hon-Chi.
Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms ,
J Physiol
 575 , 627-44 , 2006
Cells
Ventricular myocytes and mesenteric arterial SMC
Enzymes
Papain : 0.175%
Medium
Krebs-Ringer
Heart
Rat
Rat, SD, male, 250-300 g
Head, B. , Patel, H. , Roth, D. , Lai, N. , Niesman, I. , Farquhar, M. and Insel, P.
G-Protein-Coupled Receptor Signaling Components Localize in Both Sarcolemmal and Intracellular Caveolin-3-Associated Microdomains in Adult Cardiac Myocytes. ,
J Biol Chem
 280 , 31036-44 , 2005
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 250 u/ml
Medium
Cardioplegic solution
Heart
Rat
Rat, SD, 2-4 day
Entcheva, E. , Bien, H, Yin L. , Chung, C. , Farrell, M. and Kostov, Y.
Functional Cardiac Cell Constructs on Cellulose-based Scaffolding ,
Biomaterials
 25(26) , 5753 , 2004
Cells
Cardiomyocytes, fibroblasts
Enzymes
Trypsin : 0.1%
Collagenase : 0.1%
Medium
Medium 199
Heart
Rat
Rat, male, 250-300 g
Hunton DaciaL, Zou LuYun, Pang Yi, Marchase Richard B.
Adult rat cardiomyocytes exhibit capacitative calcium entry ,
Am J Physiol Heart Circ Physiol
 286 , H1124-32 , 2004
Cells
Cardiomyocytes
Enzymes
Protease : 0.01%
Medium
HBSS
Heart
Rat
Rat, neonatal
Chen Hsiao-Huei, Mullett Steven J, Stewart Alexandre F R.
Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes ,
J Biol Chem
 279 , 30800-6 , 2004
Cells
Cardiac myocytes
Enzymes
Medium
HBSS

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.