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Tissue References Search Tool

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Heart
Rat
Rat, 3 day
Ye, K. , Sullivan, K. and Black, L.
Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering. ,
J Vis Exp
 55 , 3251 , 2011
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 300 u/ml
Medium
PBS
Heart
Rat
Rat, neonatal
Guan, X. , Delo, D. , Atala, A. and Soker, S.
In Vitro Cardiomyogenic Potential of Human Amniotic Fluid Stem Cells. ,
J Tissue Eng Regen Med
 5 , 220 , 2011
Cells
Cardiomyocytes
Enzymes
Trypsin : 0.07%
Medium
DMEM/M199
Heart
Rat
Rat, adult
Louch, W. , Sheehan, K. and Wolska, B.
Methods in Cardiomyocyte Isolation, Culture, and Gene Transfer. ,
J Mol Cell Cardiol
 51 , 288-98 , 2011
Cells
Cardiomyocytes
Enzymes
Medium
see reference
Heart
Rat
Rat, Wistar, male
Brinckmann, M. , Kaschina, E. , Altarche-Xifro, W. , Curato, C. , Timm, M. , Grzesiak, A. , Dong, J. , Kappert, K. , Kintscher, U. , Unger, T. and Li, J.
Estrogen Receptor Alpha Supports Cardiomyocytes Indirectly Through Post-Infarct Cardiac c-kit+ Cells. ,
J Mol Cell Cardiol
 47 , 66 , 2009
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, neonatal
Smith, M. , Huang, Y. and Deshmukh, M.
Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway. ,
PLoS ONE
 4 , e5097 , 2009
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, adult
Xu, X. and Colecraft, H.
Primary Culture of Adult Rat Heart Myocytes. ,
J Vis Exp
 28 , 1308 , 2009
Cells
Myocytes
Enzymes
Protease XIV : 0.02%
Medium
Media 199
Heart
Rat
Rat, SD, 1-2 day
Kim, M. , Oh, J. , Sakata, S. , Liang, I. , Park, W. , Hajjar, R. and Lebeche, D.
Role of Resistin in Cardiac Contractility and Hypertrophy. ,
J Mol Cell Cardiol
 45 , 270 , 2008
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 2 day
Jang, J. , Ku, S. , Kim, J. , Choi, K. , Kim, Y. , Kim, H. , Oh, S. , Lee, E. , Cho, H. , Song, Y. , Lee, S. , Lee, S. , Suh, C. , Kim, S. , Moon, S. and Choi, Y.
Notch Inhibition Promotes Human Embryonic Stem Cell-Derived Cardiac Mesoderm Differentiation. ,
Stem Cells
 26 , 2782 , 2008
Cells
Cardiomyocytes
Enzymes
Medium
DMEM/F-12
Heart
Rat
Rat, SD, male, 225-250g
Kubli, D. , Quinsay, M. , Huang, C. , Lee, Y. and Gustafsson, A.
Bnip3 Functions as a Mitochondrial Sensor of Oxidative Stress During Myocardial Ischemia and Reperfusion. ,
Am J Physiol Heart Circ Physiol
 295 , H2025 , 2008
Cells
Cardiomyocytes
Enzymes
Medium
J-MEM
Heart
Rat
Rat, SD, 200-250 g
Farkas, A. , Acsai, K. , Nagy, N. , Toth, A. , Fulop, F. , Seprenyi, G. , Birinyi, P. , Nanasi, P. , Forster, T. , Csanady, M. , Papp, J. , Varrro, A. and Farkas, A.
Na(+)/Ca(2+) Exchanger Inhibition Exerts a Positive Inotropic Effect in the Rat Heart, but Fails to Influence the Contractility of the Rabbit Heart. ,
Br J Pharmacol
 154 , 93 , 2008
Cells
Cardiomyocytes
Enzymes
Hyaluronidase : see reference
Protease : see reference
Medium
Krebs-Henseleit
Heart
Rat
Rat, neonatal
Robinet, A. , Millart, H. , Oszust, F. , Hornebeck, W. and Bellon, G.
Binding of Elastin Peptides to S-Gal Protects the Heart Against Ischemia/Reperfusion Injury by Triggering the RISK Pathway. ,
FASEB J
 21 , 1968 , 2007
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat
Jenkins, C. , Milsted, A. , Doane, K. , Meszaros, G. , Toot, J. and Ely, D.
A Cell Culture Model using Rat Coronary Artery Adventitial Fibroblasts to Measure Collagen Production. ,
BMC Cardiovasc Disord
 7 , 13 , 2007
Cells
Ventricular fibroblasts
Enzymes
Trypsin : 0.06%
Collagenase : 100 u/ml
Medium
ADS Buffer:see reference
Heart
Rat
Rat, 2-3 day
LaFramboise, W. , Scalise, D. , Stoodley, P. , Graner, S. , Guthrie, R. , Magovern, J. and Becich, M.
Cardiac Fibroblasts Influence Cardiomyocyte Phenotype in Vitro. ,
Am J Physiol Cell Physiol
 292 , C1799-808 , 2007
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, SD, male
Stagg Mark A, Coppen Steven R, Suzuki Ken, Varela-Carver Anabel, Lee Joon, Brand Nigel J, Fukushima Satsuki, Yacoub Magdi H, Terracciano Cesare M.
Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation ,
FASEB J
 20 , 744-6 , 2006
Cells
Ventricular myocytes
Enzymes
Collagenase : 0.13%
Hyaluronidase : 0.06%
Medium
DMEM
Heart
Rat
Rat, Wistar, neonatal
Butler, T. , Au, C. , Yang, B. , Egan, J. , Tan, Y. , Hardeman, E. , North, K. , Verkman, A. and Winlaw, D.
Cardiac Aquaporin Expression in Humans, Rats, and Mice. ,
Am J Physiol Heart Circ Physiol
 291 , H705 , 2006
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, 300-350 g
Niederbichler Andreas D, Hoesel Laszlo M, Westfall Margaret V, Gao Hongwei, Ipaktchi Kyros R, Sun Lei, Zetoune Firas S, Su Grace L, Arbabi Saman, Sarma J Vidya, Wang StewartC, Hemmila MarkR, Ward PeterA.
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction ,
J Exp Med
 203 , 53-61 , 2006
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, SD, 200-250 g
Lu Tong, Ye Dan, Wang Xiaoli, Seubert John M, Graves Joan P, Bradbury J Alyce, Zeldin Darryl C, Lee Hon-Chi.
Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms ,
J Physiol
 575 , 627-44 , 2006
Cells
Ventricular myocytes and mesenteric arterial SMC
Enzymes
Papain : 0.175%
Medium
Krebs-Ringer
Heart
Rat
Rat, 1-2 day
Pedram, A. , Razandi, M. , Aitkenhead, M. and Levin, E
Estrogen Inhibits Cardiomyocyte Hypertrophy in vitro. Antagonism of Calcineurin-related Hypertrophy through Induction of MCIP1 ,
J Biol Chem
 280 , 26339 , 2005
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM/F-12
Heart
Rat
Rat, Wistar, 1-3 day
Castillo, A. , Ruzmetov, N. , Harvey, K. , Stillwell, W. , Zaloga, G. and Siddiqui, R.
Docosahexaenoic Acid Inhibits Protein Kinase C Translocation/Activation and Cardiac Hypertrophy in Rat Cardiomyocytes. ,
J Mol Genet Med
 1 , 18 , 2005
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, male, 250-300 g
Head, B. , Patel, H. , Roth, D. , Lai, N. , Niesman, I. , Farquhar, M. and Insel, P.
G-Protein-Coupled Receptor Signaling Components Localize in Both Sarcolemmal and Intracellular Caveolin-3-Associated Microdomains in Adult Cardiac Myocytes. ,
J Biol Chem
 280 , 31036-44 , 2005
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 250 u/ml
Medium
Cardioplegic solution
Heart
Rat
Rat, SD, 1-2 day
Muller-Bore, B. , Cascio, W. , Anderson, P. , Snowwaert, J. , Frye, J. , Desai, N. , Esch, G. , Brackham, J. , Bagnell, C. , Coleman, W. , Grisham, J. and Malouf, N.
Adult-derived Liver Stem Cells Acquire a Cardiomyocyte Structural and Functional Phenotype ex vivo ,
Am J Pathol
 165 , 135 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat,1-2 day
Natarajan AR, Rong Q, Katchman AN. and Ebert SN.
Intrinsic cardiac catecholamines help maintain beating activity in neonatal rat cardiomyocyte cultures ,
Pediatr Res
 56 , 411 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
DMEM
Heart
Rat
Rat, 1 day
Chen, Z. , Ge, Y. and Kang J.
Down-regulation of the M6P/IGF-II Receptor Increases Cell Proliferation and Reduces Apoptosis in Neonatal Rat Cardiac Myocytes ,
BMC Cell Biol
 5 , 15 , 2004
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
F-10
Heart
Rat
Rat, SD, 2-4 day
Entcheva, E. , Bien, H, Yin L. , Chung, C. , Farrell, M. and Kostov, Y.
Functional Cardiac Cell Constructs on Cellulose-based Scaffolding ,
Biomaterials
 25(26) , 5753 , 2004
Cells
Cardiomyocytes, fibroblasts
Enzymes
Trypsin : 0.1%
Collagenase : 0.1%
Medium
Medium 199
Heart
Rat
Rat, male, 250-300 g
Hunton DaciaL, Zou LuYun, Pang Yi, Marchase Richard B.
Adult rat cardiomyocytes exhibit capacitative calcium entry ,
Am J Physiol Heart Circ Physiol
 286 , H1124-32 , 2004
Cells
Cardiomyocytes
Enzymes
Protease : 0.01%
Medium
HBSS
Heart
Rat
Rat, neonatal
Chen Hsiao-Huei, Mullett Steven J, Stewart Alexandre F R.
Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes ,
J Biol Chem
 279 , 30800-6 , 2004
Cells
Cardiac myocytes
Enzymes
Medium
HBSS
Heart
Rat
Rat, neonatal
Tamamori-Adachi, M. , Hayashida, K. , Nobori, K. , Omizu, C. , Yamada, K. , Sakamoto, N. , Kamura, T. , Fukuda, K. , Ogawa, S. , Nakayama, K. and Kitajima, S.
Down-Regulation of p27 Promotes Cell Proliferation of Rat Neonatal Cardiomyocytes Induced by Nuclear Expression of Cyclin D1 and CDK4 ,
J Biol Chem
 2279 , 50429 , 2004
Cells
Cardiomyocytes
Enzymes
Medium
DMEM
Heart
Rat
Rat, neonatal
Li TS, Ito H, Kajiwara K. and Hamano K.
Long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and CD40 blockade ,
Circulation
 108 , 1760 , 2003
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, 50 g
Aberle II NS. and Ren J.
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy ,
Biol Proced Online
 5 , 1 , 2003
Cells
Ventricular myocytes
Enzymes
Collagenase : 223 u/ml
Hyaluronidase : 0.01%
Trypsin : 0.002%
Medium
Medium 199
Heart
Rat
Rat, adult, 220-280g
Gordon Jennifer M, Dusting Gregory J, Woodman Owen L, Ritchie Rebecca H.
Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes ,
Am J Physiol Heart Circ Physiol
 284 , H330-6 , 2003
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 178 u/ml
Hyaluronidase : 0.01%
Medium
Krebs-Henseleit, CF
Heart
Rat
Rat, fetal or 3-day
Tamamori-Adachi Mimi, Ito Hiroshi, Sumrejkanchanakij Piyamas, Adachi Susumu, Hiroe Michiaki, Shimizu Masato, Kawauchi Junya, Sunamori Makoto, Marumo Fumiaki, Kitajima Shigetaka, Ikeda Masa-Aki.
Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation ,
Circ Res
 92 , e12-9 , 2003
Cells
Cardiomyocytes
Enzymes
Medium
HEPES
Heart
Rat
Rat, SD, 200-300 g
Swift Luther, McHowat Jane, Sarvazyan Narine.
Inhibition of membrane-associated calcium-independent phospholipase A2 as a potential culprit of anthracycline cardiotoxicity ,
Cancer Res
 63 , 5992-8 , 2003
Cells
Cardiomyocytes
Enzymes
Collagenase Type 2 : 0.05-0.1%
Medium
Joklik's MEM
Heart
Rat
Rat, SD, 175-200g
Tardif Annie, Julien Nathalie, Chiasson Jean-Louis, Coderre Lise.
Stimulation of glucose uptake by chronic vanadate pretreatment in cardiomyocytes requires PI 3-kinase and p38 MAPK activation ,
Am J Physiol/Endo
 284 , E1055-64 , 2003
Cells
Cardiomyocytes
Enzymes
Medium
Krebs-Ringer
Heart
Rat
Rat, 1 day
Yang Y, Liao H, Ke Q, Cai J, Xiao YF. and Morgan JP
Enhancement of nitric oxide production by methylecgonidine in cultured neonatal rat cardiomyocytes ,
Br J Pharmacol
 135 , 188 , 2002
Cells
Cardiomyocytes
Enzymes
NCIS kit : per instructions
Medium
L-15
Heart
Rat
Rat, SD, pregnant female
DeAlmeida, A. , Mustin, D. , Forman, M. , Brower, G. , Janicki, J. and Carver, W.
Effects of mast cells on the behavior of isolated heart fibroblasts: modulation of collagen remodeling and gene expression ,
J Cell Physiol
 191 , 51 , 2002
Cells
Peritoneal mast
Enzymes
Hyaluronidase : 100 u/ml
Medium
DMEM (see reference)
Heart
Rat
Rat, female, 250-300 g
Liu Qinghang, Hofmann Polly A.
Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart ,
Am J Physiol Heart Circ Physiol
 283 , H1314-21 , 2002
Cells
Ventricular myocytes
Enzymes
Medium
Ringer solution

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.