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Tissue References Search Tool

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Stem
Mouse
Mouse, neonatal
Janebodin, K. , Horst, O. , Ieronimakis, N. , Balasundaram, G. , Reesukumal, K. , Pratumvinit, B. and Reyes, M.
Isolation and Characterization of Neural Crest-Derived Stem Cells from Dental Pulp of Neonatal Mice. ,
PLoS ONE
 6 , e27526 , 2011
Cells
Dental pulp stem
Enzymes
Medium
PBS
Stem
Mouse
Mouse
Rountree, C. , Ding, W. , Dang, H. , Vankirk, C. and Crooks, G.
Isolation of CD133+ Liver Stem Cells for Clonal Expansion. ,
J Vis Exp
 56 , e3183 , 2011
Cells
CD133+ stem
Enzymes
Pronase : 0.05%
Medium
DMEM/F12
Stem
Mouse
Mouse
Rasheed, Z. , Wang, Q. and Matsui, W.
Isolation of Stem Cells from Human Pancreatic Cancer Xenografts. ,
J Vis Exp
 43 , 2169 , 2010
Cells
Pancreatic cancer stem
Enzymes
Collagenase Type 4 : 200 u/ml
Neutral Protease : 0.6 u/ml
Medium
DMEM
Stem
Mouse
Mouse, postnatal
Sher, F. , Rossler, R. , Brouwer, N. , Balasubramaniyan, V. , Boddeke, E. and Copray, S.
Differentiation of Neural Stem Cells Into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2. ,
Stem Cells
 26 , 2875 , 2008
Cells
Astrocytes
Enzymes
Trypsin : 0.25%
Deoxyribonuclease I : 1,000 u/ml
Medium
HBSS
Stem
Mouse
Mouse, 12 week
Taddei, I. , Deugnier, M. , Faraldo, M. , Petit, V. , Bouvard, D. , Medina, D. , Fassler, R. , Thiery, J. and Glukhova, M.
Beta1 Integrin Deletion from the Basal Compartment of the Mammary Epithelium Affects Stem Cells ,
Nat Cell Biol
 10 , 716-22 , 2008
Cells
Mammary epithelial
Enzymes
Collagenase : 0.3%
Hyaluronidase : 100 u/ml
Trypsin : 0.25%
Medium
see reference
Stem
Mouse
Mouse, 6-8 week
Bi Yanming, Ehirchiou Driss, Kilts Tina M, Inkson Colette A, Embree Mildred C, Sonoyama Wataru, Li Li, Leet Arabella I, Seo Byoung-Moo, Zhang Li, Shi Songtao, Young Marian F.
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche ,
Nat Med
 13 , 1219-27 , 2007
Cells
Tendon stem/progenitor
Enzymes
Medium
DMEM
Stem
Mouse
Mouse
Li Wen-Lin, Su Juan, Yao Yu-Cheng, Tao Xin-Rong, Yan Yong-Bi, Yu Hong-Yu, Wang Xin-Min, Li Jian-Xiu, Yang Yong-Ji, Lau Joseph T Y, Hu Yi-Ping.
Isolation and characterization of bipotent liver progenitor cells from adult mouse ,
Stem Cells
 24 , 322-32 , 2006
Cells
Liver epithelial progenitor cells
Enzymes
Medium
DMEM
Stem
Mouse
Mouse, day 7
Lee, A, Kessler, J, Read, T, Kaiser, C, Corbeil, D, Huttner ,W, Johnson, J, Wechsler-Reya, R.
Isolation of Neural Stem Cells from the Postnatal Cerebellum ,
Nat Neurosci
 8 , 723 , 2005
Cells
Cerebellar stem cells
Enzymes
Papain : 10u/ml
Deoxyribonuclease I : 250 u/ml
Medium
Dulbecco's PBS
Stem
Mouse
Mouse, 8-10 week
Kotton, D. , Fabian, A. and Mulligan, R.
A Novel Stem-Cell Population in Adult Liver with Potent Hematopoietic-Reconstitution Activity. ,
Blood
 106 , 1574 , 2005
Cells
Liver derived stem cells
Enzymes
Medium
HBSS
Stem
Mouse
Mouse
Bertoncello, I. and Williams, B.
Hematopoietic Stem Cell Characterization by Hoechst 33342 and Rhodamine 123 Staining. ,
Methods Mol Biol
 263 , 181 , 2004
Cells
Bone marrow
Enzymes
Medium
PBS
Stem
Mouse
Mouse, 4-7 day
Howell, J. , Lee, W. , Morrison, P. , Zhong, J. , Yoder, M. and Srour, E.
Pluripotent Stem Cells Identified in Multiple Murine Tissues. ,
Ann N Y Acad Sci
 996 , 158 , 2003
Cells
Pluripotent stem cells
Enzymes
Collagenase Type 1 : 220 u/ml
Neutral Protease : 33 u/ml
Medium
MEM
Stem
Mouse
Mouse
Boulanger CA, Smith GH.
Reducing mammary cancer risk through premature stem cell senescence ,
Oncogene
 20 , 2264-72 , 2001
Cells
Mammary epithelial stem
Enzymes
Hyaluronidase : 0.1%
Pronase : 1.25%
Medium
DMEM
Stem
Ovine
Ovine, 3-5 year
Letouzey, V. , Tan, K. , Deane, J. , Ulrich, D. , Gurung, S. , Ong, Y. and Gargett, C.
Isolation and Characterisation of Mesenchymal Stem/Stromal Cells in the Ovine Endometrium. ,
PLoS ONE
 10 , e0127531 , 2015
Cells
Endometrial stromal
Enzymes
Medium
DMEM/F-12
Stem
Porcine
Porcine, male, 8 day
Dirami G, Ravindranath N, Pursel V, Dym M.
Effects of stem cell factor and granulocyte macrophage-colony stimulating factor on survival of porcine type A spermatogonia cultured in KSOM ,
Biol Reprod
 61 , 225-30 , 1999
Cells
Seminiferous epithelial cells
Enzymes
Collagenase : 0.15%
Hyaluronidase : 0.15%
Trypsin : 0.05%
Medium
DMEM/F12
Stem
Rabbit
Rabbit, New Zealand, 8-10 week
Zhang, J. and Wang, J.
Characterization of Differential Properties of Rabbit Tendon Stem Cells and Tenocytes. ,
BMC Musculoskelet Disord
 11 , 10 , 2010
Cells
Tenocytes and tendon stem cells
Enzymes
Medium
DMEM
Stem
Rat
Rat
Jiang, H. , Zhang, Y. , Tian, K. , Wang, B. and Han, S.
Amelioration of Experimental Autoimmune Encephalomyelitis Through Transplantation of Placental Derived Mesenchymal Stem Cells. ,
Sci Rep
 7 , 41837 , 2017
Cells
Placental mesenchymal
Enzymes
Medium
DMEM
Stem
Rat
Rat, adult
Duarte, S. , Momier, D. , Baque, P. , Casanova, V. , Loubat, A. , Samson, M. , Guigonis, J. , Staccini, P. , Saint-Paul, M. , De Lima, M. , Carle, G. and Pierrefite-Carle, V.
Preventive Cancer Stem Cell-Based Vaccination Reduces Liver Metastasis Development in a Rat Colon Carcinoma Syngeneic Model. ,
Stem Cells
 31 , 423-32 , 2013
Cells
Tumor
Enzymes
Medium
DMEM/F12
Stem
Rat
Rat, SD, neonatal
Liu, Z. , Wang, H. , Zhang, Y. , Zhou, J. , Lin, Q. , Wang, Y. , Duan, C. , Wu, K. and Wang, C.
Efficient Isolation of Cardiac Stem Cells from Brown Adipose. ,
J Biomed Biotechnol
 2010 , 104296 , 2010
Cells
Brown adipocytes
Enzymes
Medium
PBS
Stem
Rat
Rat, male, 200-250 g
Gobbel GT, Choi SJ, Beier S, Niranjan A.
Long-term cultivation of multipotential neural stem cells from adult rat subependyma ,
Brain Res
 980 , 221 , 2003
Cells
Neural stem cells
Enzymes
Papain : 0.09%
Medium
EBSS
Stem
Rat
Rat, SD, embyronic
Bixby, S. , Kruger, G. , Mosher, J. , Joseph, N. and Morrison, S.
Cell-Intrinsic Differences Between Stem Cells from Different Regions of the Peripheral Nervous System Regulate the Generation of Neural Diversity. ,
Neuron
 35 , 643 , 2002
Cells
Sciatic nerve and gut neural crest stem
Enzymes
Trypsin : 0.005%
Medium
HBSS
Stem
Rat
Rat, adult
Palmer, T. , Markakis, E. , Willhoite, A. , Safar, F. and Gage, F.
Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS ,
J Neurosci
 19 , 8487 , 1999
Cells
Neural stem cells
Enzymes
Papain : 2.5 u/ml
Deoxyribonuclease I : 250 u/ml
Neutral Protease : 1 u/ml
Medium
DMEM/F-12
Stem
Rat
Rat
Ray, J. and Gage, F.
Neural Stem Cell Isolation, Characterization and Transplantation , Modern Techniques in Neuroscience Research , Johansson, H. and Windhorst, U. , Springer-Verlag New York , 339 , 1999
Cells
Central nervous system stem cells
Enzymes
Papain : 0.01%
Medium
DMEM/F-12
Thymus
Human
Human
Vandenabeele S, Hochrein H, Mavaddat N, Winkel K, Shortman K.
Human thymus contains 2 distinct dendritic cell populations ,
Blood
 97 , 1733-41 , 2001
Cells
Dentritic
Enzymes
Medium
RPMI 1640
Thymus
Mouse
Mouse
Rode, I. and Boehm, T.
Regenerative Capacity of Adult Cortical Thymic Epithelial Cells. ,
Proc Natl Acad Sci U S A
 109 , 3463-8 , 2012
Cells
Thymic stromal
Enzymes
Medium
RPMI-1640
Thymus
Mouse
Mouse
Schiavoni, F, Mattei, F, Sestili, P, Borghi, P, Venditti, M, Morse, H, Belardelli, F. and Gabrieli, L
ICSBP is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8a+ Dendritic Cells ,
J Exp Med
 196 , 1415 , 2002
Cells
Dentritic
Enzymes
Medium
RPMI 1640
Thymus
Mouse
Mouse (BALB/c, C3H, C57BL/6), 1-28 day
Ropke, C. , van Deurs, B. and Petersen, O.
Short-term Cultivation of Murine Thymic Epithelial Cells in a Serum-Free Medium ,
In Vitro Cell Dev Biol
 26 , 671 , 1990
Cells
Epithelial, thymus
Enzymes
Neutral Protease : 1.5 µg/ml
Medium
DMEM
Thyroid/Parathyroid
Bovine
Bovine, adult
Nygren, P. , Gylfe, E. , Larsson, R. , Johansson, H. , Juhlin, C. , Klareskoq, L. , Akerstrom, G. and Rastad, J.
Modulation of the Ca2+-Sensing Function of Parathyroid Cells In Vitro and in Hyperparathyroidism ,
Biochim Biophys Acta
 968 , 253 , 1988
Cells
Parathyroid
Enzymes
Medium
HEPES Ham's F10
Thyroid/Parathyroid
Bovine
Bovine
Wallace, J. and Scarpa, A.
Regulation of Parathyroid Hormone Secretion in Vitro by Divalent Cations ,
J Biol Chem
 257 , 10613 , 1982
Cells
Parathyroid glands
Enzymes
Medium
HEPES buffer
Thyroid/Parathyroid
Bovine
Bovine
Brown, E. , Hurwitz, S. and Aurbach, G.
Preparation of Viable Isolated Bovine Parathyroid Cells ,
Endocrinology
 99 , 1582 , 1976
Cells
Parathyroid
Enzymes
Medium
Eagle's #2 medium without bicarbonate
Thyroid/Parathyroid
Human
Human
Gianoukakis, A. , Cao, H. , Jennings, T. and Smith, T.
Prostaglandin Endoperoxide H Synthase Expression in Human Thyroid Epithelial Cells. ,
Am J Physiol Cell Physiol
 280 , C701 , 2001
Cells
Thyrocytes
Enzymes
Collagenase Type 1 : 130 u/ml
Neutral Protease : 0.5 u/ml
Medium
HBSS
Thyroid/Parathyroid
Human
Human
Howie, A. , Walker, S. , Akesson, B. , Arthur, J. and Beckett, G.
Thyroidal Extracellular Glutathione Peroxidase: A Potential Regulator of Thyroid-Hormone Synthesis. ,
Biochem J
 308 ( Pt 3) , 713 , 1995
Cells
Thyrocytes
Enzymes
Trypsin : 0.25%
Collagenase : 0.1%
Medium
EBSS
Thyroid/Parathyroid
Mouse
Mouse
Kitajima, S. , Kohno, S. , Kondoh, A. , Sasaki, N. , Nishimoto, Y. , Li, F. , Mohammed, M. , Muranaka, H. , Nagatani, N. , Suzuki, M. , Kido, Y. and Takahashi, C.
Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. ,
Stem Cells
 33 , 1657-69 , 2015
Cells
Thyroid tumor
Enzymes
Collagenase Type 1 : 300 u/ml
Hyaluronidase : 100 u/ml
Medium
DMEM
Thyroid/Parathyroid
Mouse
Mouse, 6 week
Martin, A. , Coronel, E. , Sano, G. , Chen, S. , Vassileva, G. , Canasto-Chibuque, C. , Sedgwick, J. , Frenette, P. , Lipp, M. , Furtado, G. and Lira, S.
A Novel Model for Lymphocytic Infiltration of the Thyroid Gland Generated by Transgenic Expression of the CC Chemokine CCL21. ,
J Immunol
 173 , 4791 , 2004
Cells
Thyroid
Enzymes
Neutral Protease : 0.0012 u/ml
Collagenase Type 2 : 0.25 u/ml
Medium
RPMI 1640
Tonsil
Human
Human, female, 25-45 year
Grammer Amrie C, Slota Rebecca, Fischer Randy, Gur Hanan, Girschick Hermann, Yarboro Cheryl, Illei Gabor G, Lipsky PeterE.
Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions ,
J Clin Invest
 112 , 1506-20 , 2003
Cells
Tonsillar mononuclear cells
Enzymes
Medium
RPMI
Tonsil
Human
Human
Grammer AC, McFarland RD, Heaney J, Darnell BF, Lipsky PE.
Expression, regulation, and function of B cell-expressed CD154 in germinal centers ,
J Immunol
 163 , 4150-9 , 1999
Cells
Tonsillar mononuclear cells
Enzymes
Medium
RPMI
Tumor
Hamster
Hamster, 6 week old
Min, B. , Kim, K. , Cherrick, H. and Park, N.
Three Cell Lines from Hamster Buccal Pouch Tumors Induced by Topical 7,12-Dimethylbenz(a)Anthracene, Alone or in Conjunction with Herpes Simplex Virus Inoculation ,
In Vitro Cell Dev Biol
 27A , 128 , 1991
Cells
Buccal pouch
Enzymes
Medium
CMF HBSS

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.