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Tissue References Search Tool

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Neural
Mouse
Mouse, male
Roberts, L. and MacDonald, C.and Mark, C.
Anandamide is a Partial Agonist at Native Vanilloid Receptors in Acutely Isolated Mouse Trigeminal Sensory Neurons. ,
Br J Pharmacol
 137 , 421 , 2002
Cells
Trigeminal senesory neurons
Enzymes
Papain : 20 u/ml
Medium
HEPES buffered saline
Neural
Mouse
Mouse, postnatal-day-1-old (P1)
Deshmukh, M. , Kuida, K. and Johnson Jr., E.
Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization ,
J Cell Biol
 150 (1) , 131 , 2000
Cells
Neurons
Enzymes
Trypsin : 0.25%
Medium
NGF-containing medium
Neural
Mouse
Mouse embryos
Lee, K. , Davies, A. and Jaenisch, R.
P75-Eficient Embryonic Dorsal Root Sensory and Neonatal Sympathetic Neurons Display a Decreased Sensitivity to NGF ,
Development
 120 , 1027 , 1994
Cells
Neurons, DRG and SCG
Enzymes
Trypsin : 0.25%
Medium
L-15 medium
Neural
Mouse
mouse, 65 days
Richards L. , Kilpatrick T. and Bartlett P.
De Novo Generation of Neuronal Cells from the Adult Mouse Brain ,
Proc Natl Acad Sci U S A
 89 , 8591 , 1992
Cells
Neurons, neuronal precursors
Enzymes
Trypsin : 0.1%
Medium
DMEM
Neural
Mouse
Mouse, CD-1, neonate
Quinn, S. and De Boni, U.
Enhanced Neuronal Regeneration by Retinoic Acid of Murine Dorsal Root Ganglia and of Fetal Murine and human Spinal Cord in vitro ,
In Vitro Cell Dev Biol
 27 , 55 , 1991
Cells
Neurons, dorsal root ganglion
Enzymes
Trypsin : 0.25%
Medium
HBSS
Neural
Mouse
Mouse, fetal
Kitani, H. , Shiurba, R. , Sakakura, T. and Tomooka, Y.
Isolation and Characterization Of Mouse Neural Precursor Cells in Primary Culture ,
In Vitro Cell Dev Biol
 27 , 615 , 1991
Cells
Precursor
Enzymes
Trypsin : 0.5%
Medium
PBS
Neural
Mouse
Mouse, neonatal
(also chick)
Varon, S. , Skaper, S. , Barbin, G. , Selak, I. and Manthorpe, M.
Low Molecular Weight Agents Support Survival of Cultured Neurons From the Central Nervous System ,
J Neurosci
 4 (3) , 654 , 1984
Cells
PNS test neurons
Enzymes
Trypsin : 0.08%
Medium
Eagle's Basal Medium (see reference)
Neural
Ovine
Lamb
(also calf)
Poduslo, S. , Miller, K. and McKhann, G.
Metabolic Properties of Maintained Oligodendroglia Purified from Brain ,
J Biol Chem
 253 , 1592 , 1978
Cells
Oligodendroglia
Neural
Enzymes
Trypsin : 0.1%
Medium
(see reference)
Neural
Porcine
Porcine, adult, 60-100 kg
Si ML, Lee TJ.
Presynaptic alpha7-nicotinic acetylcholine receptors mediate nicotine-induced nitric oxidergic neurogenic vasodilation in porcine basilar arteries ,
J Pharmacol Exp Ther
 298 , 122 , 2001
Cells
Superior cervical ganglia
Enzymes
Papain : 2 u/ml
Collagenase : 0.12%
Medium
HBSS
Neural
Quail
Quail
Sieber-Blum, M. and Cohen, A.
Clonal Analysis of Quail Neural Crest Cells: They are Pluripotent and Differentiate in Vitro in the Absence of Noncrest Cells ,
Dev Biol
 80 , 96 , 1980
Cells
Neural crest
Enzymes
Trypsin : 0.05%
Medium
MEM, HBSS
Neural
Rat
Rat, SD, day 2
Maurel, P.
Preparation of Neonatal Rat Schwann Cells and Embryonic Dorsal Root Ganglia Neurons for In Vitro Myelination Studies. ,
Methods Mol Biol
 1739 , 17-37 , 2018
Cells
Schwann
Enzymes
Trypsin : 0.25%
Medium
DMEM
Neural
Rat
Rat, SD, p7
Clements, M. , Byrne, E. , Camarillo Guerrero, L. , Cattin, A. , Zakka, L. , Ashraf, A. , Burden, J. , Khadayate, S. , Lloyd, A. , Marguerat, S. and Parrinello, S.
The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration. ,
Neuron
 96 , 98-114.e7 , 2017
Cells
Schwann
Enzymes
Medium
DMEM
Neural
Rat
Rat, SD
Andersen, N. , Srinivas, S. , Pinero, G. and Monje, P.
A Rapid and Versatile Method for the Isolation, Purification and Cryogenic Storage of Schwann Cells from Adult Rodent Nerves. ,
Sci Rep
 6 , 31781 , 2016
Cells
Schwann
Enzymes
Trypsin : 0.25%
Medium
DMEM
Neural
Rat
Rat, embryonic
Oyanagi, K. , Tashiro, T. and Negishi, T.
Cell-Type-Specific and Differentiation-Status-Dependent Variations in Cytotoxicity of Tributyltin in Cultured Rat Cerebral Neurons and Astrocytes. ,
J Toxicol Sci
 40 , 459-68 , 2015
Cells
Cerebral neurons
Enzymes
Papain : 2 u/ml
Medium
DMEM-PBS
Neural
Rat
Rat, SD
Wei, X. , Yan, J. , Tillu, D. , Asiedu, M. , Weinstein, N. , Melemedjian, O. , Price, T. and Dussor, G.
Meningeal Norepinephrine Produces Headache Behaviors in Rats via Actions Both on Dural Afferents and Fibroblasts. ,
Cephalalgia
 35 , 1054-64 , 2015
Cells
Trigeminal ganglion
Enzymes
Papain : 20 u/ml
Medium
DMEM/F12
Neural
Rat
Rat, neonatal
Stettner, M. , Lohmann, B. , Wolffram, K. , Weinberger, J. , Dehmel, T. , Hartung, H. , Mausberg, A. and Kieseier, B.
Interleukin-17 Impedes Schwann Cell-Mediated Myelination. ,
J Neuroinflammation
 11 , 63 , 2014
Cells
Schwann cells
Enzymes
Collagenase : 0.05-0.1%
Trypsin : 0.125-0.25%
Medium
DMEM
Neural
Rat
Rat, 1-3 day
Thurner, P. , Gsandtner, I. , Kudlacek, O. , Choquet, D. , Nanoff, C. , Freissmuth, M. and Zezula, J.
A Two-State Model for the Diffusion of the A2A Adenosine Receptor in Hippocampal Neurons: Agonist-Induced Switch to Slow Mobility is Modified by Synapse-Associated Protein 102 (SAP102). ,
J Biol Chem
 289 , 9263-74 , 2014
Cells
Hippocampal neurons
Enzymes
Papain : 25 u/ml
Medium
L-15
Neural
Rat
Rat, E18
Todd, G. , Boosalis, C. , Burzycki, A. , Steinman, M. , Hester, L. , Shuster, P. and Patterson, R.
Towards Neuronal Organoids: A Method for Long-Term Culturing of High-Density Hippocampal Neurons. ,
PLoS ONE
 8 , e58996 , 2013
Cells
Hippocampal neurons
Enzymes
Papain : 0.2%
Medium
Hibernate
Neural
Rat
Rat, SD, 175-200 g
Yan, J. , Melemedjian, O. , Price, T. and Dussor, G.
Sensitization of Dural Afferents Underlies Migraine-Related Behavior Following Meningeal Application of Interleukin-6 (IL-6). ,
Mol Pain
 8 , 6 , 2012
Cells
Trigeminal ganglia
Enzymes
Papain : 20 u/ml
Medium
HBSS
Neural
Rat
Rat, Wistar, E18
Giacomello, M. , Girardi, S. , Scorzeto, M. , Peruffo, A. , Maschietto, M. , Cozzi, B. and Vassanelli, S.
Stimulation of Ca²+ Signals in Neurons by Electrically Coupled Electrolyte-Oxide-Semiconductor Capacitors. ,
J Neurosci Methods
 198 , 1 , 2011
Cells
Neurons
Enzymes
Papain : 0.05%
Medium
Neurobasal
Neural
Rat
Rat, 20-30 day
Bosmans, F. , Puopolo, M. , Martin-Eauclaire, M. , Bean, B. and Swartz, K.
Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors. ,
J Gen Physiol
 138 , 59 , 2011
Cells
Dorsal root ganglion
Enzymes
Papain : 20 u/ml
Medium
L-15
Neural
Rat
Rat, SD, E18
Peltier, D. , Simms, A. , Farmer, J. and Miller, D.
Human Neuronal Cells Possess Functional Cytoplasmic and TLR-Mediated Innate Immune Pathways Influenced by Phosphatidylinositol-3-Kinase Signaling ,
J Immunol
 184 , 7010 , 2010
Cells
Neuronal
Enzymes
Papain : 0.2%
Medium
Neurobasal E
Neural
Rat
Rat, Fisher, 7-21 month
Chen, N. , Newcomb, J. , Garbuzova-Davis, S. , Davis Sanberg, C. , Sanberg, P. and Willing, A.
Human Umbilical Cord Blood Cells Have Trophic Effects on Young and Aging Hippocampal Neurons in Vitro. ,
Aging Dis
 1 , 173 , 2010
Cells
Hippocampal neurons
Enzymes
Papain : 0.2%
Medium
Hibernate A
Neural
Rat
Rat, SD, embryonic day 18
Liu, Y. , Yohrling, G. , Wang, Y. , Hutchinson, T. , Brenneman, D. , Flores, C. and Zhao, B.
Carisbamate, a Novel Neuromodulator, Inhibits Voltage-Gated Sodium Channels and Action Potential Firing of Rat Hippocampal Neurons. ,
Epilepsy Res
 83 , 66 , 2009
Cells
Hippocampal neurons
Enzymes
Papain : 20 u/ml
Medium
Neurobasal/B27
Neural
Rat
Rat, embryonic
Yokosuka Makoto, Ohtani-Kaneko Ritsuko, Yamashita Kayoko, Muraoka Daisuke, Kuroda Yoichiro, Watanabe Chiho.
Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias ,
Toxicol In Vitro
 22 , 1-9 , 2008
Cells
Hypothalamic neurons and glias
Enzymes
Papain : 0.5 u/ml
Medium
DMEM
Neural
Rat
Rat, neonatal
Frank, L. , Caldera-Siu, A. and Pothos, E.
Primary Dissociated Midbrain Dopamine Cell Cultures from Rodent Neonates. ,
J Vis Exp
 21 , 820 , 2008
Cells
Dopamine neurons
Enzymes
Papain : 20 u/ml
Medium
PBS
Neural
Rat
Rat, SD, 1-2 day
Floyd Candace L, Gorin Fredric A, Lyeth Bruce G.
Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes ,
Glia
 51 , 35-46 , 2005
Cells
Cortical astrocytes
Enzymes
Papain : see reference
Medium
DMEM
Neural
Rat
Rat, SD, male, 5-8 week
Connor, M, Naves, L. and McCleskey, E.
Contrasting Phenotypes of Putative Proprioceptive and Nociceptive Trigeminal Neurons Innervating Jaw Muscle in Rat. ,
Mol Pain
 1 , 31 , 2005
Cells
Trigeminal neurons
Enzymes
Papain : 20 u/ml
Collagenase : 0.3%
Medium
CMF Hanks
Neural
Rat
Rat, SD, 0-2 day
Pedraza Carlos E, Podlesniy Petar, Vidal Noemi­, Arevalo Juan Carlos, Lee Ramee, Hempstead Barbara, Ferrer Isidre, Iglesias Montse, Espinet Carme.
Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR ,
Am J Pathol
 166 , 533-43 , 2005
Cells
Superior cervical ganglion
Enzymes
Collagenase Type 4 : 20 u/ml
Trypsin : 0.25%
Medium
DMEM
Neural
Rat
Rat, Wistar, E15
Moriya-Ito K, Osada T, Ishimatsu Y, Muramoto K, Kobayashi T, Ichikawa M.
Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons ,
Chem Senses
 30 , 111 , 2005
Cells
Vomeronasal receptor neurons
Enzymes
Papain : 0.5 u/ml
Medium
DMEM/F12
Neural
Rat
Rat, SD, male 150-220 g
Hu Hong-Zhen, Gu Qihai, Wang Chunbo, Colton Craig K, Tang Jisen, Kinoshita-Kawada Mariko, Lee Lu-Yuan, Wood Jackie D, Zhu Michael X.
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3 ,
J Biol Chem
 279 , 35741-8 , 2004
Cells
Dorsal root ganglion neurons
Enzymes
Trypsin : 0.05%
Medium
DMEM/Ham's F12
Neural
Rat
Rat, 15 week
Evans J, Sumners C, Moore J, Huentelman MJ, Deng J, Gelband CH. and Shaw G
Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem ,
J Neurophysiol
 87 , 1076 , 2002
Cells
Neurons
Enzymes
Papain : 0.2%
Medium
Hibernate A
Neural
Rat
Rat, Fisher, 8-9 week
Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH.
The adult substantia nigra contains progenitor cells with neurogenic potential ,
J Neurosci
 22 , 6639 , 2002
Cells
Adult progenitor
Enzymes
Papain : 2.5 u/ml
Deoxyribonuclease I : 250 u/ml
Neutral Protease : 1 u/ml
Medium
DMEM/F-12
Neural
Rat
Rat, SD, embryonic
Bixby, S. , Kruger, G. , Mosher, J. , Joseph, N. and Morrison, S.
Cell-Intrinsic Differences Between Stem Cells from Different Regions of the Peripheral Nervous System Regulate the Generation of Neural Diversity. ,
Neuron
 35 , 643 , 2002
Cells
Sciatic nerve and gut neural crest stem
Enzymes
Trypsin : 0.005%
Medium
HBSS
Neural
Rat
Rat
Liu, Q. , Kawai, H. and Berg, D.
B-Amyloid Peptide Blocks the Response of a7-Containing Nicotinic Receptors on Hippocampal Neurons ,
PNAS
 98 (8) , 4734 , 2001
Cells
Neurons, hippocampal
Enzymes
Papain : 15 - 20 u/ml
Medium
Eagle's MEM
(see reference)
Neural
Rat
Rat, newborn, 7 days old
Acosta, C. , Fabrega, A. , Masco, D. and Lopez, H.
A Sensory Neuron Subpopulation with Unique Sequential Survival Dependence on Nerve Growth Factor and Basic Fibroblast Growth Factor during Development ,
J Neurosci
 21 (22) , 8873 , 2001
Cells
Neurons
Enzymes
Trypsin : 0.25%
Medium
MEM10

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.