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Adipose/Fat
Mouse

Mouse, Adult

Hay, A. , Murphy, T. , Popichak, K. , Zabel, M. and Moreno, J.
Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro. ,
Sci Rep
 12 , 22567 , 2022
Cells
Mesenchymal stromal
Enzymes
Stemxyme 1 : 400u/ml
Medium
DMEM/F12
Adipose/Fat
Mouse
Mouse
Jones, J. , Rabhi, N. , Orofino, J. , Gamini, R. , Perissi, V. , Vernochet, C. and Farmer, S.
The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. ,
Sci Rep
 10 , 2380 , 2020
Cells
Adipocytes
Enzymes
Medium
DMEM
Adipose/Fat
Mouse
Mouse
Bowles, A. , Strong, A. , Wise, R. , Thomas, R. , Gerstein, B. , Dutreil, M. , Hunter, R. , Gimble, J. and Bunnell, B.
Adipose Stromal Vascular Fraction-Mediated Improvements at Late-Stage Disease in a Murine Model of Multiple Sclerosis. ,
Stem Cells
 35 , 532-544 , 2017
Cells
Adipose stromal
Enzymes
Medium
HBSS
Adipose/Fat
Mouse
Mouse
Yao, W. , Lay, Y. , Kot, A. , Liu, R. , Zhang, H. , Chen, H. , Lam, K. and Lane, N.
Improved Mobilization of Exogenous Mesenchymal Stem Cells to Bone for Fracture Healing and Sex Difference. ,
Stem Cells
 34 , 2587-2600 , 2016
Cells
Adipose stromal
Enzymes
Medium
PBS
Adipose/Fat
Mouse
Mouse
Maria, O. , Shalaby, M. , Syme, A. , Eliopoulos, N. and Muanza, T.
Adipose Mesenchymal Stromal Cells Minimize and Repair Radiation-Induced Oral Mucositis. ,
Cytotherapy
 18 , 1129-45 , 2016
Cells
Adipose mesenchyal stromal
Enzymes
Medium
DMEM
Adipose/Fat
Mouse
Mouse
Jang, H. , Bhasin, S. , Guarneri, T. , Serra, C. , Schneider, M. , Lee, M. , Guo, W. , Fried, S. , Pencina, K. and Jasuja, R.
The Effects of A Single Developmentally-Entrained Pulse of Testosterone in Female Neonatal Mice On Reproductive and Metabolic Functions in Adult Life. ,
Endocrinology
 156 , 3737 , 2015
Cells
Adipocytes
Enzymes
Collagenase : 0.1%
Medium
Krebs
Adipose/Fat
Mouse
Mouse
Seaman, S. , Tannan, S. , Cao, Y. , Peirce, S. and Lin, K.
Differential Effects of Processing Time and Duration of Collagenase Digestion on Human and Murine Fat Grafts. ,
Plast Reconstr Surg
 136 , 189e-199e , 2015
Cells
Adipocytes
Enzymes
Medium
PBS
Adipose/Fat
Mouse
Mouse, 20 week
Kondo, T, Toyoshima, Y. , Ishii, Y. and Kyuwa, S.
Natural Killer T Cells in Adipose Tissue are Activated in Lean Mice. ,
Exp Anim
 62 , 319 , 2013
Cells
Stromal vascular
Enzymes
Medium
RPMI-1640
Adipose/Fat
Mouse
Mouse
Takahashi, H. , Haraguchi, N. , Nishikawa, S. , Miyazaki, S. , Suzuki, Y. , Mizushima, T. , Nishimura, J. , Takemasa, I. , Yamamoto, H. , Mimori, K. , Ishii, H. , Doki, Y. and Mori, M.
Biological and Clinical Availability of Adipose-Derived Stem Cells for Pelvic Dead Space Repair. ,
Stem Cells Transl Med
 1 , 803 , 2012
Cells
Adipose derived stem
Enzymes
Medium
DMEM
Adipose/Fat
Mouse
Mouse
Han, J. , Koh, Y. , Moon, H. , Ryoo, H. , Cho, C. , Kim, I. and Koh, G.
Adipose Tissue is an Extramedullary Reservoir for Functional Hematopoietic Stem and Progenitor Cells. ,
Blood
 115 , 957 , 2010
Cells
Stem and progenitor
Enzymes
Medium
HBSS
Adipose/Fat
Mouse
Mouse
Wong, K. , Szeto, F, Zhang, W. , Ye, H. , Kong, J. , Zhang, Z. , Sun, X. and Li, Y
Involvement of the Vitamin D Receptor in Energy Metabolism: Regulation of Uncoupling Proteins. ,
Am J Physiol/Endo
 296 , 820 , 2009
Cells
White adipocytes
Enzymes
Medium
DMEM
Adipose/Fat
Mouse
Mouse
Thangarajah, H. , Vial, I. , Chang, E. , El-Ftesi, S. , Januszyk, M. , Chang, E. , Paterno, J. , Neofytou, E. , Longaker, M. and Gurtner, G.
IFATS Collection: Adipose Stromal Cells Adopt a Proangiogenic Phenotype Under the Influence of Hypoxia. ,
Stem Cells
 27 , 266 , 2009
Cells
Adipose stromal
Enzymes
Medium
DMEM
Adipose/Fat
Mouse
Mouse, 3 week
De Matteis, R. , Zingaretti, M. , Murano, I. , Vitali, A. , Frontini, A. , Giannulis, I. , Barbatelli, G. , Marcucci, F. , Bordicchia, M. , Sarzani, R. , Raviola, E. and Cinti, S.
In Vivo Physiological Transdifferentiation of Adult Adipose Cells. ,
Stem Cells
 27 , 2761 , 2009
Cells
Adipocytes
Enzymes
Medium
HBSS
Adipose/Fat
Mouse
Mouse
Cho, K. , Park, H. , Park, H. , Jung, J. , Jeon, S. , Kim, Y. and Roh, H.
IFATS Collection: Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells in an Allergic Rhinitis Mouse Model. ,
Stem Cells
 27 , 259-65 , 2009
Cells
Adipose tissue-derived stem
Enzymes
Medium
Modified Eagles
Adipose/Fat
Mouse
Mouse, C57Bl/6J
Aoyagi T, Shimba S, Tezuka M.
Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes ,
J Health Sci
 51 , 21 , 2005
Cells
Adipocytes
Enzymes
Medium
DMEM/F12
Adipose/Fat
Mouse
Mouse
Planat-Benard Valerie, Silvestre Jean-Sebastien, Cousin Beatrice, Andre Mireille, Nibbelink Maryse, Tamarat Radia, Clergue Michel, Manneville Carole, Saillan-Barreau Corinne, Duriez Micheline, Tedgui Alain, Levy Bernard, Penicaud Luc, Casteilla Louis.
Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives ,
Circulation
 109 , 656-63 , 2004
Cells
Stromal vascular, adipocytes
Enzymes
Collagenase : 0.2%
Medium
DMEM/F12
Adipose/Fat
Mouse
Mouse, 3-6 day and 2-3 month
Cowan Catherine M, Shi Yun-Ying, Aalami Oliver O, Chou Yu-Fen, Mari Carina, Thomas Romy, Quarto Natalina, Contag Christopher H, Wu Benjamin, Longaker Michael T.
Adipose-derived adult stromal cells heal critical-size mouse calvarial defects ,
Nat Biotechnol
 22 , 560-7 , 2004
Cells
Adipose-derived stromal cells
Enzymes
Medium
PBS
Adipose/Fat
Mouse
Mouse, C57BL/6J and FVB, male, 8-9 week
Ruan, H. , Zarnowski, MJ. , Cushman, S. and Lodish, H.
Standared Isolation of Primary Adipose Cells from Mouse Epididymal Fat Pads Induces Inflammatory Mediators and Down-regulates Adipocyte Genes ,
J Biol Chem
 278 , 47585 , 2003
Cells
Adipocytes
Enzymes
Collagenase : see reference
Medium
DMEM
Adipose/Fat
Mouse
Mouse, both sexes
Nadler, S. , Stoehr, J. , Rabaglia, M. , Schueler, K. , Birnbaum, M. and Attie, A.
Normal Akt/PKB with Reduced PI3K Activation in Insulin-resistant Mice ,
Am J Physiol/Endo
 281 , E1249 , 2001
Cells
Adipocytes
Enzymes
Collagenase : 0.05%
Medium
Krebs-Ringer Phosphate HEPES (KRPH)
Adipose/Fat
Mouse
Mouse, B6D2F1, F1 hybrids, New Zealand black female & New Zealand white male
Launder, T. , Gegen, N. , Knedler, A. and Harbeck, R.
The Isolation and Characterization of Enriched Microvascular Endothelial Cells From Mouse Adipose Tissue ,
J Immunol Methods
 102 , 45 , 1987
Cells
Vascular endothelial
Enzymes
Collagenase : 0.2%
Medium
PBS
Intestine
Mouse

Mouse

Kumar, S. , Suman, S. , Li, H. , Angdisen, J. , Datta, K. and Fornace, A.
High-linear Energy Transfer Radiation Disrupts Natural Killer Cell Surveillance of Senescent Intestinal Cells in the Mouse Intestine. , Mol Biomed Vol. 7 , 2026
Cells
Organoids
Enzymes
Medium
HBSS
Intestine
Mouse

Mouse, adult

Kumar, S. , Suman, S. , Angdisen, J. , Moon, B. , Kallakury, B. , Datta, K. and Fornace, A.
Effects of High-Linear-Energy-Transfer Heavy Ion Radiation on Intestinal Stem Cells: Implications for Gut Health and Tumorigenesis. ,
Cancers
 16 , 2024
Cells
Intestinal stem
Enzymes
Medium
HBSS
Intestine
Mouse
Mouse
Emgard, J. , Kammoun, H. , Garcia-Cassani, B. , Chesne, J. , Parigi, S. , Jacob, J. , Cheng, H, Evren, E. , Das, S. , Czarnewski, P. , Sleiers, N. Melo-Gonzalez, F. , Kvedaraite, E. Svensson, M. and Scandella, E.
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. ,
Immunity
 48 , 120-132.e8 , 2018
Cells
Lamina propria lymphocytes
Enzymes
Medium
HBSS
Intestine
Mouse
Mouse, embryonic
Ren HJ, Zhang CL, Liu RD, Li N, Li XG, Xue HK, Guo Y, Wang ZQ, Cui J. and Ming L
Primary Cultures of Mouse Small Intestinal Epithelial Cells using the Dissociating Enzyme Type I Collagenase and Hyaluronidase. ,
Braz J Med Biol Res
 50 , e5831 , 2017
Cells
Crypt
Enzymes
Collagenase Type 1 : 200 u/ml
Hyaluronidase : 100u/ml
Medium
DMEM
Intestine
Mouse
Mouse
O'Rourke, K. , Ackerman, S. , Dow, L. and Lowe, S.
Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells. ,
Bio Protoc
 6 , 2016
Cells
Intestinal organoids
Enzymes
Medium
Basal Medium
Intestine
Mouse
Mouse
Seo, S. , Kuffa, P. , Kitamoto, S. , Nagao-Kitamoto, H. , Rousseau, J. , Kim, Y. , Nunez, G. and Kamada, N.
Intestinal Macrophages Arising from CCR2(+) Monocytes Control Pathogen Infection by Activating Innate Lymphoid Cells. ,
Nat Commun
 6 , 8010 , 2015
Cells
Lamina propria mononuclear cells
Enzymes
Medium
HBSS
Intestine
Mouse
Mouse
Beura, L. , Anderson, K. , Schenkel, J. , Locquiao, J. , Fraser, K. , Vezys, V. , Pepper, M. and Masopust, D.
Lymphocytic Choriomeningitis Virus Persistence Promotes Effector-Like Memory Differentiation and Enhances Mucosal T cell Distribution. ,
J Leukoc Biol
 97 , 217 , 2015
Cells
Lymphocytes
Enzymes
Collagenase Type 1 : 100 u/ml
Medium
RPMI-1640
Intestine
Mouse
Zhang, Y. and Hu, W.
Mouse Enteric Neuronal Cell Culture. ,
Methods Mol Biol
 1078 , 55-63 , 2013
Cells
Enteric neurons
Enzymes
Trypsin : 0.05%
Deoxyribonuclease I : 400 u/ml
Medium
DMEM/F12
Intestine
Mouse
Mouse, P4
Hotta, R. , Stamp, L. , Foong, J. , McConnell, S. , Bergner, A. , Anderson, R. , Enomoto, H. , Newgreen, D. , Obermayr, F. , Furness, J. and Young, H.
Transplanted Progenitors Generate Functional Enteric Neurons in the Postnatal Colon. ,
J Clin Invest
 123 , 1182 , 2013
Cells
Enteric neural crest progenitors
Enzymes
Medium
DMEM/F12
Intestine
Mouse
Mouse
Xue, X. and Shah, Y.
In Vitro Organoid Culture of Primary Mouse Colon Tumors. ,
J Vis Exp
 , e50210 , 2013
Cells
Colon tumor organoids
Enzymes
Medium
DMEM
Intestine
Mouse
Mouse
Geem, D. , Medina-Contreras, O. , Kim, W. , Huang, C. and Denning T.
Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine. ,
J Vis Exp
 63 , e4040 , 2012
Cells
Dendritic, macrophages
Enzymes
Collagenase : 0.15%
Medium
HBSS
Intestine
Mouse
Mouse, 2-3 month
Becker, L. , Kulkarni, S. , Tiwari, G. , Micci, M. and Pasricha, P.
Divergent Fate and Origin of Neurosphere-Like Bodies from Different Layers of the Gut. ,
Am J Physiol Gastrointest Liver Physiol
 302 , G958-65 , 2012
Cells
Enteric neural stem cells
Enzymes
Medium
M199
Intestine
Mouse
Mouse
Barthel, E. , Speer, A. , Levin, D. , Sala, F. , Hou, X. , Torashima, Y. , Wigfall, C. and Grikscheit, T.
Tissue Engineering of the Intestine in a Murine Model. ,
J Vis Exp
 70 , e4279 , 2012
Cells
Intestinal organoids
Enzymes
Collagenase Type 1 : 800 u/ml
Neutral Protease : 0.013%
Medium
DMEM
Intestine
Mouse
Mouse
Ruiz, V. , Sachdev, M. , Zhang, S. , Wen, S. and Moss, S.
Isolating, Immunophenotyping and Ex vivo Stimulation of CD4+ and CD8+ Gastric Lymphocytes During Murine Helicobacter Pylori Infection. ,
J Immunol Methods
 384 , 157-63 , 2012
Cells
Lyphocytes
Enzymes
Medium
RPMI 1640
Intestine
Mouse
Mouse, neonatal and adult
Joseph, N. , He, S. , Quintana, E. , Kim, Y. , Nunez, G. and Morrison, S.
Enteric Glia are Multipotent in Culture but Primarily Form Glia in the Adult Rodent Gut. ,
J Clin Invest
 121 , 3398 , 2011
Cells
Myenteric plexus
Enzymes
Collagenase Type 4 : 0.025-0.1%
Papain : 10 u/ml
Deoxyribonuclease I : 100 u/ml
Medium
HBSS
Intestine
Mouse
Mouse
Ito, Y. , Kanai, T. , Totsuka, T. , Okamoto, R. , Tsuchiya, K. , Nemoto, Y. , Yoshioka, A. , Tomita, T. , Nagaishi, T. , Sakamoto, N. , Sakanishi, T. , Okumura, K. , Yagita, H. and Watanabe, M.
Blockade of NKG2D Signaling Prevents the Development of Murine CD4+ T Cell-Mediated Colitis. ,
Am J Physiol Gastrointest Liver Physiol
 294 , G199 , 2008
Cells
Lamina propria lymphocytes
Enzymes
Medium
RPMI 1640

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.