For our international customers, please be advised that orders cannot be placed through our website by customers in countries with International Distributor representation.

Quick Order

Tissue References Search Tool

Search
Endothelial
Mouse
Mouse, 4 week
Esteban, S. , Clemente, C. , Koziol, A. , Gonzalo, P. , Rius, C. , Martinez, F. , Linares, P. , Chaparro, M. , Urzainqui, A. , Andres, V. , Seiki, M. , Gisbert, J. and Arroyo, A.
Endothelial MT1-MMP Targeting Limits Intussusceptive Angiogenesis and Colitis via TSP1/Nitric Oxide Axis. ,
EMBO Mol Med
 12 , e10862 , 2020
Cells
Aortic endothelial
Enzymes
Elastase : 0.25%
Medium
DMEM
Endothelial
Mouse
Mouse, 2 month
Sabbagh, M. and Nathans, J.
A Genome-wide View of the De-differentiation of Central Nervous System Endothelial Cells in Culture ,
Elife
 , 1 , 2020
Cells
Endothelial, CNS
Enzymes
PDS kit : with modifications
Stemxyme 1 : 0.1%
Medium
EC growth medium
Endothelial
Mouse
Mouse
Luo, S. , Truong, A. and Makino, A.
Isolation of Mouse Coronary Endothelial Cells. ,
J Vis Exp
 , 2016
Cells
Coronary endothelial
Enzymes
Medium
Kreb's
Endothelial
Mouse
Mouse
Wang, J. , Sun, C. , Gerdes, N. , Liu, C. , Liao, M. , Liu, J. , Shi, M. , He, A. , Zhou, Y. , Sukhova, G. , Chen, H. , Cheng, X. , Kuzuya, M. , Murohara, T. , Zhang, J. , Cheng, X. , Jiang, M. , Shull, G. and Rogers, S.
Interleukin 18 Function in Atherosclerosis is Mediated by the Interleukin 18 Receptor and the Na-Cl Co-Transporter. ,
Nat Med
 21 , 820-6 , 2015
Cells
Endothelial lung
Enzymes
Medium
DMEM
Endothelial
Mouse
Mouse
Xiao, L. , McCann, J. and Dudley, A.
Isolation and Culture Expansion of Tumor-specific Endothelial Cells. ,
J Vis Exp
 , e53072 , 2015
Cells
Endothelial
Enzymes
Medium
DMEM
Endothelial
Mouse
Mouse
Kochukov, M. , Balasubramanian, A. , Abramowitz, J. , Birnbaumer, L. and Marrelli, S.
Activation of Endothelial Transient Receptor Potential C3 Channel is Required for Small Conductance Calcium-Activated Potassium Channel Activation and Sustained Endothelial Hyperpolarization and Vasodilation of Cerebral Artery. ,
J Am Heart Assoc
 3 , 2014
Cells
Cerebral artery endothelial
Enzymes
Neutral Protease : 4 u/ml
Elastase : 1 u/ml
Collagenase Type 1 : 120 u/ml
Medium
DMEM
Endothelial
Mouse
Mouse
Kazerounian, S. , Gerald, D. , Huang, M. , Chin, R, Udayakumar, D, Zheng, N. , O'Donnell, R. , Perruzzi, C. , Mangiante, L. , Pourat, J. , Phung, T. , Bravo-Nuevo, A. , Shechter, S. , McNamara, S. and Duhadaway, K.
RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells During Breast Tumorigenesis. ,
Cancer Res
 73 , 50 , 2013
Cells
Tumor endothelial
Enzymes
Medium
HBSS
Endothelial
Mouse
Mouse, 8-14 week
Imoukhuede, P. and Popel, A.
Expression of VEGF Receptors on Endothelial Cells in Mouse Skeletal Muscle. ,
PLoS ONE
 7 , e44791 , 2012
Cells
Endothelial
Enzymes
Medium
HBSS
Endothelial
Mouse
Mouse
Daneman, R. , Zhou, L. , Agalliu, D. , Cahoy, J. , Kaushal, A. and Barres, B.
The Mouse Blood-Brain Barrier Transcriptome: a New Resource for Understanding the Development and Function of Brain Endothelial Cells. ,
PLoS ONE
 5 , e13741 , 2010
Cells
Endothelial
Enzymes
Papain : 40 u/ml
Deoxyribonuclease I : 125 u/ml
Medium
DPBS
Endothelial
Mouse
Mouse, 7-10 week
Follenzi, A. , Benten, D. , Novikoff, P. , Faulkner, L. , Raut, S. and Gupta, S.
Transplanted Endothelial Cells Repopulate the Liver Endothelium and Correct the Phenotype of Hemophilia A Mice. ,
J Clin Invest
 118 , 935 , 2008
Cells
Liver endothelial
Enzymes
Collagenase : 0.03%
Medium
DMEM
Endothelial
Mouse
Mouse, 4 week
Kondo, S. , Scheef, E. , Sheibani, N. and Sorenson, C.
PECAM-1 Isoform-Specific Regulation of Kidney Endothelial Cell Migration and Capillary Morphogenesis. ,
Am J Physiol Cell Physiol
 292 , C2070 , 2007
Cells
Endothelial kidney
Enzymes
Medium
DMEM
Endothelial
Mouse
Mouse, embryonic or yolk sac
Braren Rickmer, Hu Huiqing, Kim YungHae, Beggs HilaryE, Reichardt LouisF, Wang Rong.
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation ,
J Cell Biol
 172 , 151-62 , 2006
Cells
Endothelial
Enzymes
Medium
PBS
Endothelial
Mouse
Mouse, neonatal
Cha, S. , Talavera, D. , Demir, E. , Nath, A. and Sierra-Honigmann, M.
A Method of Isolation and Culture of Microvascular Endothelial Cells from Mouse Skin. ,
Microvasc Res
 70 , 198 , 2005
Cells
Microvascular endothelial
Enzymes
Medium
DMEM
Endothelial
Mouse
Mouse, 4 week
Su X, Sorenson CM. and Sheibani N.
Isolation and characterization of murine retinal endothelial cells ,
Mol Vis
 9 , 171 , 2003
Cells
Retinal endothelial cells
Enzymes
Medium
DMEM
Endothelial
Mouse
Mouse, male
Izawa D, Tanaka T, Saito K, Ogihara H, Usui T, Kawamoto S, Matsubara K, Okubo K. and Miyasaka M
Expression profile of active genes in mouse lymph node high endothelial cells ,
Int Immunol
 11(12) , 1989 , 1999
Cells
Endothelial cells from lymph node
Enzymes
Medium
PBS
Endothelial
Mouse
Mouse, 2-4 week
Sapatino, B. , Welsh, C. , Smith, C. , Bebo, B. and Linticum, D.
Cloned Mouse Cerebrovascular Endothelial Cells That Maintain Their Differentiation Markers for Factor VIII, Low Density Lipoprotein, and Angiotensin-Converting Enzyme ,
In Vitro Cell Dev Biol
 29A , 923 , 1993
Cells
Cerebrovascular Endothelial
Enzymes
Medium
PBS
Tumor
Mouse

Mouse

Nahar, S. , Huang, Y. , Nagy, B. , Zebala, J. , Maeda, D. , Rudloff, U. , Oppenheim, J. and And, D
Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies. , Cancers (Basel) Vol. 15 , 2023
Cells
Tumor
Enzymes
Tumor
Mouse
Mouse
Walker, S. , Wankell, M. , Ho, V. , White, R. , Deo, N. , Devine, C. , Dewdney, B. , Bhathal, P. , Govaere, O. , Roskams, T. , Qiao, L. , George, J. and Hebbard, L.
Targeting mTOR and Src Restricts Hepatocellular Carcinoma Growth in a Novel Murine Liver Cancer Model. ,
PLoS ONE
 14 , e0212860 , 2019
Cells
liver tumor
Enzymes
Medium
HBSS
Tumor
Mouse
Mouse, adult
Neal, J,, Li ,X. , Zhu, J. , Giangarra, V. , Grzeskowiak, C. , Ju, J. , Liu, I. Chiou, S. , Salahudeen, A. and Smith, A. et al
Organoid Modeling of the Tumor Immune Microenvironment. ,
Cell
 175 , 1972 , 2018
Cells
Organoids
Enzymes
Collagenase Type 4 : 200-300 u/ml
Medium
DMEM
Tumor
Mouse
Mouse
Erdreich-Epstein, A. , Singh, A. , Joshi, S. , Vega, F. , Guo, P. , Xu, J. , Groshen, S. , Ye, W. , Millard, M. , Campan, M. , Morales, G. , Garlich, J. , Laird, P. , Seeger, R. , Shimada, H. and Durden, D.
Association of High Microvessel A,B and Low PTEN with Poor Outcome in Stage 3 Neuroblastoma: Rationale for Using First in Class Dual PI3K/BRD4 Inhibitor, SF1126. ,
Oncotarget
 8 , 52193-52210 , 2017
Cells
Tumor derived neutroblastoma
Enzymes
Papain : 10 u/ml
Deoxyribonuclease I : 250 u/ml
Medium
DPBS
Tumor
Mouse
Mouse
Boyd, N. , Walker, K. , Fried, J. , Hackney, J. , McDonald, P. , Benavides, G. , Spina, R. , Audia, A. , Scott, S. , Libby, C. , Tran, A. , Bevensee, M. , Griguer, C. , Nozell, S. , Gillespie, G. and Nabors, B.
Addition of Carbonic Anhydrase 9 Inhibitor SLC-0111 to Temozolomide Treatment Delays Glioblastoma Growth In Vivo. ,
JCI Insight
 2 , 2017
Cells
Glioblastoma
Enzymes
PDS kit : per instructions
Medium
DMEM/F12
Tumor
Mouse
Mouse
Aguilera, T. , Rafat, M. , Castellini, L. , Shehade, H. , Kariolis, M. , Hui, A. , Stehr, H. , von Eyben, R. , Jiang, D. , Ellies, L. , Koong, A. , Diehn, M. , Rankin, E. Graves, E. and Giaccia, A.
Reprogramming the Immunological Microenvironment through Radiation and Targeting Axl. ,
Nat Commun
 7 , 13898 , 2016
Cells
Tumor
Enzymes
Collagenase : 0.1%
Neutral Protease : 0.5 u/ml
Medium
F12K
Tumor
Mouse
Mouse
Otvos, B. , Silver, D. , Mulkearns-Hubert, E. , Alvarado, A. , Turaga, S. , Sorensen, M. , Rayman, P. , Flavahan, W. , Hale, J. , Stoltz, K. , Sinyuk, M. , Wu, Q. , Jarrar, A. , Kim, S. , Fox, P. , Nakano, I. and Rich, J.
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion. ,
Stem Cells
 34 , 2026-39 , 2016
Cells
Glioblastoma
Enzymes
PDS kit : per instructions
Medium
Neurobasal
Tumor
Mouse
Mouse
Filtjens, J. , Keirsse, J. , Van Ammel, E. , Taveirne, S. , Van Acker, A. , Kerre, T. , Taghon, T. , Vandekerckhove, B. , Plum, J. , Van Ginderachter, J. and Leclercq, G.
Expression of the Inhibitory Ly49E Receptor is Not Critically Involved in the Immune Response Against Cutaneous, Pulmonary or Liver tumours. ,
Sci Rep
 6 , 30564 , 2016
Cells
Tumor
Enzymes
Medium
RPMI-1640
Tumor
Mouse
Mouse
Singer, M. , Wang, C. , Cong, L. , Marjanovic, N. , Kowalczyk, Mo. , Zhang, H. , Nyman, J. , Sakuishi, K. , Kurtulus, S. , Gennert, D. , Xia, J. , Kwon, J. , Nevin, J. , Herbst, R. , Yanai, I. , Rozenblatt-Rosen, O. and Kuchroo, V.
A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. ,
Cell
 166 , 1500-1511.e9 , 2016
Cells
Tumor-infiltrating lymphocytes
Enzymes
Medium
DMEM
Tumor
Mouse
Mouse
Hosseini, H. , Obradovic, M. , Hoffmann, M. , Harper, K. , Sosa, M. , Werner-Klein, M. , Nanduri, L. , Werno, C. , Ehrl, C. , Maneck, M. , Patwary, N. , Haunschild, G. , Guzvic, M. and Reimelt, C. et al.
Early Dissemination Seeds Metastasis in Breast Cancer. ,
Nature
 , 2016
Cells
Mammary tumor
Enzymes
Collagenase Type 1 : 200 u/ml
Hyaluronidase : 0.001%
Medium
DMEM/F12
Tumor
Mouse
Mouse
Blanco, S. , Bandiera, R. , Popis, M. , Hussain, S. , Lombard, P. , Aleksic, J. , Sajini, A. , Tanna, H. , Cortes-Garrido, R. , Gkatza, N. , Dietmann, S. and Frye, M.
Stem Cell Function and Stress Response are Controlled by Protein Synthesis. ,
Nature
 534 , 335-40 , 2016
Cells
Keratinocytes
Enzymes
Medium
Low calcium containing media
Tumor
Mouse
Mouse
Kitajima, S. , Kohno, S. , Kondoh, A. , Sasaki, N. , Nishimoto, Y. , Li, F. , Mohammed, M. , Muranaka, H. , Nagatani, N. , Suzuki, M. , Kido, Y. and Takahashi, C.
Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. ,
Stem Cells
 33 , 1657-69 , 2015
Cells
Thyroid tumor
Enzymes
Collagenase Type 1 : 300 u/ml
Hyaluronidase : 100 u/ml
Medium
DMEM
Tumor
Mouse
Mouse
Xiao, L. , McCann, J. and Dudley, A.
Isolation and Culture Expansion of Tumor-specific Endothelial Cells. ,
J Vis Exp
 , e53072 , 2015
Cells
Endothelial
Enzymes
Medium
DMEM
Tumor
Mouse
Mouse
Ali, O. , Verbeke, C. , Johnson, C. , Sands, R. , Lewin, S. , White, D. , Doherty, E. , Dranoff, G. and Mooney, D.
Identification of Immune Factors Regulating Antitumor Immunity Using Polymeric Vaccines with Multiple Adjuvants. ,
Cancer Res
 74 , 1670-81 , 2014
Cells
Tumor
Enzymes
Collagenase Type 1 : 250 u/ml
Medium
DMEM
Tumor
Mouse
Mouse
Devaud, C. , Westwood, J. , John, L. , Flynn, J. , Paquet-Fifield, S. , Duong, C. , Yong, C. , Pegram, H. , Stacker, S. , Achen, M. Stewart, T. , Snyder, L. , Teng, M. , Smyth, M. , Darcy, P. and Kershaw, M
Tissues in Different Anatomical Sites can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy. ,
Mol Ther
 22 , 18-27 , 2014
Cells
Tumor
Enzymes
Medium
PBS
Tumor
Mouse
Mouse
Dunleavey, J. , Xiao, L. , Thompson, J. , Kim, M. , Shields, J. , Shelton, S. , Irvin, D. , Brings, V. , Ollila, D. , Brekken, R. , Dayton, P. , Melero-Martin, J. and Dudley, A.
Vascular Channels Formed by Subpopulations of PECAM1+ Melanoma Cells. ,
Nat Commun
 5 , 5200 , 2014
Cells
Tumor
Enzymes
Medium
DMEM
Tumor
Mouse
Mouse
Liu, X. , Johnson, S. , Liu, S. , Kanojia, D. , Yue, W. , Singh, U. , Wang, Q, Wang Qi, Nie, Q. and Chen H.
Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy. ,
Sci Rep
 3 , 2473 , 2013
Cells
Mammary tumor
Enzymes
Collagenase : 0.15%
Hyaluronidase : 0.020%
Medium
DMEM/F12
Tumor
Mouse
Mouse
Kazerounian, S. , Gerald, D. , Huang, M. , Chin, R, Udayakumar, D, Zheng, N. , O'Donnell, R. , Perruzzi, C. , Mangiante, L. , Pourat, J. , Phung, T. , Bravo-Nuevo, A. , Shechter, S. , McNamara, S. and Duhadaway, K.
RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells During Breast Tumorigenesis. ,
Cancer Res
 73 , 50 , 2013
Cells
Tumor endothelial
Enzymes
Medium
HBSS
Tumor
Mouse
Mouse
Chen, X. , Stewart, E. , Shelat, A. , Qu, C. , Bahrami, A. , Hatley, M. , Wu, G. , Bradley, C. , McEvoy, J. , Pappo, A. , Spunt, S. , Valentine, M. , Valentine, V. , Krafcik, F. , Lang, W. , Wierdl, M. and Tsurkan, L.
Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma. ,
Cancer Cell
 24 , 710-24 , 2013
Cells
Rhabdomycosarcoma tumor
Enzymes
Trypsin : 0.012%
Medium
DMEM
Tumor
Mouse
Mouse
Sharon, Y. , Alon, L. , Glanz, S. , Servais, C. and Erez, N.
Isolation of Normal and Cancer-Associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting (FACS). ,
J Vis Exp
 71 , e4425 , 2013
Cells
Fibroblasts
Enzymes
Medium
DMEM

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.