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Tissue References Search Tool

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Stem
Human
Human, adult, male
Papini S, Cecchetti D, Campani D, Fitzgerald W, Grivel J, Chen S, Margolis L, Revoltella R.
Isolation and Clonal Analysis of Human Epidermal Keratinocyte Stem Cells in Long-term Culture ,
Stem Cells
 21 , 481 , 2003
Cells
Human epidermal keratinocyte stem cells
Enzymes
Medium
DMEM
Stem
Human
Human, 7-8 yr
Miura, M. , Gronthos, S, Zhao, M, Lu, B, Fisher, L, Robey, P. and Shi, S.
SHED: Stem Cells from Human Exfoliated Deciduous Teeth ,
Proc Natl Acad Sci U S A
 100 , 5807 , 2003
Cells
Stem cells Human exfoliated deciduous teeth
Enzymes
Medium
see reference
Stem
Human
Human, fetal
Malhi, H. , Irani, A. , Gagandeep, S. and Gupta, S.
Isolation of Human Progenitor Liver Epithelial Cells with Extensive Replication Capacity and Differentiation into Mature Hepatocytes. ,
J Cell Sci
 115 , 2679 , 2002
Cells
Epithelial progenitor
Enzymes
Collagenase : 0.03%
Medium
DMEM
Stem
Human
Human
Zuk, P. , Zhu, M. , Ashjian, P. , De Ugarte, D. , Huang, J. , Mizuno, H. , Alfonso, Z. , Fraser, J. , Benhaim, P. and Hedrick, M.
Human adipose tissue is a source of multipotent stem cells ,
Mol Biol Cell
 13 , 4279-95 , 2002
Cells
Processed lipoaspirate cells
Enzymes
Medium
PBS
Stem
Human
Human
Zhang, S. , Wernig, M. , Duncan, I. , Brustle, O. and Thomson, J.
In Vitro Differentiation of Transplantable Neural Precursors from Human Embryonic Stem Cells ,
Nat Biotechnol
 19 , 1129 , 2001
Cells
Stem, embryonic
Enzymes
Neutral Protease : 0.01% - 0.02%
Medium
DMEM
Stem
Human
Human, adult
Kambe, N, Kambe, M, Kochan, J. and Schwartz ,L.
Human Skin-derived Mast Cells Can Proliferate While Retaining Their Characteristic Functional and Protease Phenotypes ,
Blood
 97 , 2045 , 2001
Cells
Human skin mast cells
Enzymes
Medium
HBSS
Stem
Human
Human
Uchida, N. , Buck, D. , He, D. , Reitsma, M. , Masek, M. , Phan, T. , Tsukamoto, A. , Gage, F. and Weissman, I.
Direct Isolation of Human Central Nervous System Stem Cells. ,
Proc Natl Acad Sci U S A
 97 , 14720 , 2000
Cells
Central nervous system stem
Enzymes
Collagenase : 0.1%
Hyaluronidase : 0.1%
Medium
HBSS
Stem
Human
Human
Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM.
Embryonic stem cell lines derived from human blastocysts ,
Science
 282 , 1145-7 , 1998
Cells
Embryonic stem
Enzymes
Medium
DMEM
Stem
Human
Human
Alessandri Giulio, Pagano Stefano, Bez Alessandra, Benetti Anna, Pozzi Stefano, Iannolo Gioacchin, Baronio Manuela, Invernici Gloria, Caruso Arnaldo, Muneretto Claudio, Bisleri Gianluigi, Parati Eugenio.
Isolation and culture of human muscle-derived stem cells able to differentiate into myogenic and neurogenic cell lineages ,
Lancet
 364 , 1872-83
Cells
Muscle-derived stem cells
Enzymes
Trypsin : 0.25%
Medium
DMEM/F12
Stem
Insect
Drosophila, larval
Berger, C. , Harzer, H. , Burkard, T. , Steinmann, J. , van der Horst, S. , Laurenson, A. , Novatchkova, M. , Reichert, H. and Knoblich, J.
FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal. ,
Cell Rep
 2 , 407 , 2012
Cells
Neuroblasts
Enzymes
Papain : 0.1%
Medium
Rinaldini solution
File
11089.pdf (2.38 MB)
Stem
Monkey
Monkey
Chen, S. , Revoltella, R. , Papini, S. , Michelini, M. , Fitzgerald, W. and Zimmerberg, J.,and Margolis, L.
Multilineage Differentiation of Rhesus Monkey Embryonic Stem cells in Three-dimensional Culture Systems ,
Stem Cells
 21(3) , 281 , 2003
Cells
Embryonic stem
Enzymes
Medium
DMEM
Stem
Monkey
Baboons, 1yr, 7yr, 14 yr
Nagano, M. , McCarrey, J. and Brinster, R.
Primate Spermatogonial Stem Cells Colonize Mouse Testes ,
Biol Reprod
 64 , 1409 , 2001
Cells
Primate spermatogonial
Enzymes
Medium
DMEM
Stem
Mouse

Mouse, adult

Kumar, S. , Suman, S. , Angdisen, J. , Moon, B. , Kallakury, B. , Datta, K. and Fornace, A.
Effects of High-Linear-Energy-Transfer Heavy Ion Radiation on Intestinal Stem Cells: Implications for Gut Health and Tumorigenesis. ,
Cancers
 16 , 2024
Cells
Intestinal stem
Enzymes
Medium
HBSS
File
Kumar.2024.pdf (1.22 MB)
Stem
Mouse
Mouse, GFP transgenic
Birbrair, A, Sattiraju, A, Zhu, D, Zulato, G, Batista, I, Nguyen, V, Messi M, Solingapuram Sai, K, Marini, F, Delbono, O. and Mintz, A.
Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. ,
Stem Cells Transl Med
 , 2016
Cells
Muscle derived NLSC
Enzymes
Medium
DMEM
File
11498.pdf (2.18 MB)
Stem
Mouse
Mouse
Maria, O. , Shalaby, M. , Syme, A. , Eliopoulos, N. and Muanza, T.
Adipose Mesenchymal Stromal Cells Minimize and Repair Radiation-Induced Oral Mucositis. ,
Cytotherapy
 18 , 1129-45 , 2016
Cells
Adipose mesenchyal stromal
Enzymes
Medium
DMEM
File
11572.pdf (859.67 KB)
Stem
Mouse
Mouse, xenograft
Pham, K. , Delitto, D. , Knowlton, A. , Hartlage, E. , Madhavan, R. , Gonzalo, D. , Thomas, R. , Behrns, K. , George, T. , Hughes, S. , Wallet, S. , Liu, C. and Trevino, J.
Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture. ,
Am J Pathol
 186 , 2016
Cells
Pancreatic cancer
Enzymes
Stemxyme 1 : 0.2%
Medium
HBSS
File
11492.pdf (3.81 MB)
Stem
Mouse
Mouse
Chavez, M. , Hu, J. , Seidel, K. , Li, C. , Jheon, A. , Naveau, A. , Horst, O. and Klein, O.
Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor. ,
J Vis Exp
 , 2014
Cells
Epithelial stem
Enzymes
Medium
DMEM/F12
File
11536.pdf (2.55 MB)
Stem
Mouse
Mouse, 3-4 week
Wang, H. , Chen, H. , Feng, B. , Wang, X. , He, X. , Hu, R. , Yin, M. , Wang, W. , Fu, W. and Xu, Z.
Isolation and Characterization of a Sca-1+/CD31- Progenitor Cell Lineage Derived From Mouse Heart Tissue. ,
BMC Biotechnol
 14 , 75 , 2014
Cells
Cardiac progenitor
Enzymes
Medium
DMEM
File
11074.pdf (1.41 MB)
Stem
Mouse
Mouse, 8-12 week
Huch, M. , Bonfanti, P. , Boj, S. , Sato, T. , Loomans, C. , Van de Wetering, M. , Sojoodi, M. , Li, V. , Schuijers, J. , Gracanin, A. , Ringnalda, F. , Begthel, H. , Hamer, K. , Mulder, J. , Van Es, J. and De Koning, E.
Unlimited In Vitro Expansion of Adult Bi-Potent Pancreas Progenitors Through the Lgr5/R-Spondin Axis. ,
EMBO J
 32 , 2708-21 , 2013
Cells
Pancreas organoid
Enzymes
Neutral Protease : 0.012%
Collagenase : 0.012%
Medium
DMEM
File
11021.pdf (2.37 MB)
Stem
Mouse
Mouse
Liu, X. , Johnson, S. , Liu, S. , Kanojia, D. , Yue, W. , Singh, U. , Wang, Q, Wang Qi, Nie, Q. and Chen H.
Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy. ,
Sci Rep
 3 , 2473 , 2013
Cells
Mammary tumor
Enzymes
Collagenase : 0.15%
Hyaluronidase : 0.020%
Medium
DMEM/F12
Stem
Mouse
Mouse, adult
Martin, L. and Seandel, M.
Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-Term Adult Mouse SSC Lines. ,
J Vis Exp
 72 , e50017 , 2013
Cells
Spermatogonial stem
Enzymes
Trypsin : 0.05%
Medium
DMEM
File
10904.pdf (431.51 KB)
Stem
Mouse
Mouse
Jensen, U. , Ghazizadeh, S. and Owens, D.
Isolation and Characterization of Cutaneous Epithelial Stem Cells. ,
Methods Mol Biol
 989 , 61-9 , 2013
Cells
Epithelial stem
Enzymes
Trypsin : 0.25%
Medium
HBSS
File
11456.pdf (386.28 KB)
Stem
Mouse
Mouse, P4
Hotta, R. , Stamp, L. , Foong, J. , McConnell, S. , Bergner, A. , Anderson, R. , Enomoto, H. , Newgreen, D. , Obermayr, F. , Furness, J. and Young, H.
Transplanted Progenitors Generate Functional Enteric Neurons in the Postnatal Colon. ,
J Clin Invest
 123 , 1182 , 2013
Cells
Enteric neural crest progenitors
Enzymes
Medium
DMEM/F12
File
10914.pdf (4.06 MB)
Stem
Mouse
Mouse, 4-6 week
Masaki, T. , Qu, J. , Cholewa-Waclaw, J. , Burr, K. , Raaum, R. and Rambukkana, A.
Reprogramming Adult Schwann Cells to Stem Cell-Like Cells by Leprosy Bacilli Promotes Dissemination of Infection. ,
Cell
 152 , 51 , 2013
Cells
Schwann
Enzymes
Trypsin : 0.125%
Medium
DMEM
File
11070.pdf (4.73 MB)
Stem
Mouse
Mouse
Mazzoleni, S. , Jachetti, E. , Morosini, S. , Grioni, M. , Piras, I. , Pala, M. , Bulfone, A. , Freschi, M. , Bellone, M. and Galli, R.
Gene Signatures Distinguish Stage-Specific Prostate Cancer Stem Cells Isolated From Transgenic Adenocarcinoma of the Mouse Prostate Lesions and Predict the Malignancy of Human Tumors. ,
Stem Cells Transl Med
 2 , 678 , 2013
Cells
Prostate tumor
Enzymes
Collagenase Type 4 : 1,600 u/ml
Medium
DMEM/F12
Stem
Mouse
Mouse
Xue, X. and Shah, Y.
In Vitro Organoid Culture of Primary Mouse Colon Tumors. ,
J Vis Exp
 , e50210 , 2013
Cells
Colon tumor organoids
Enzymes
Medium
DMEM
Stem
Mouse
Mouse, 6-8 week
Bracko, O. , Singer, T. , Aigner, S. , Knobloch, M. , Winner, B. , Ray, J. , Clemenson, G. , Suh, H. , Couillard-Despres, S. , Aigner, L. , Gage, F. and Jessberger, S.
Gene Expression Profiling of Neural Stem Cells and their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal Neurogenesis. ,
J Neurosci
 32 , 3376-87 , 2012
Cells
Neural stem cells
Enzymes
Medium
DMEM/F12
File
11387.pdf (2.68 MB)
Stem
Mouse
Mouse
Vaughan, A. , Halbert, C. , Wootton, S. and Miller, A.
Lung Cancer in Mice Induced by the Jaagsiekte Sheep Retrovirus Envelope Protein is not Maintained by Rare Cancer Stem Cells, but Tumorigenicity does Correlate with Wnt Pathway Activation. ,
Mol Cancer Res
 10 , 86 , 2012
Cells
Lung tumor
Enzymes
Neutral Protease : 50 u/ml
Collagenase : 400 u/ml
Medium
DMEM
File
11083.pdf (1.7 MB)
Stem
Mouse
Mouse, P4-5
Ziegler, A. , Schneider, J. , Qin, M. , Tyler, W. , Pintar, J. , Fraidenraich, D. , Wood, T. and Levison, S.
IGF-II Promotes Stemness of Neural Restricted Precursors. ,
Stem Cells
 30 , 1265 , 2012
Cells
Neuroshere
Enzymes
Trypsin : 0.25%
Papain : 100 u
Medium
Pro-N
Stem
Mouse
Mouse, 10 week
Futami, I. , Ishijima, M. , Kaneko, H. , Tsuji, K. , Ichikawa-Tomikawa, N. , Sadatsuki, R. , Muneta, T. , Arikawa-Hirasawa, E. , Sekiya, I. and Kaneko, K.
Isolation and Characterization of Multipotential Mesenchymal Cells from the Mouse Synovium. ,
PLoS ONE
 7 , e45517 , 2012
Cells
Synovial mesenchymal
Enzymes
Medium
DMEM
File
10944.pdf (2.96 MB)
Stem
Mouse
Mouse
Barthel, E. , Speer, A. , Levin, D. , Sala, F. , Hou, X. , Torashima, Y. , Wigfall, C. and Grikscheit, T.
Tissue Engineering of the Intestine in a Murine Model. ,
J Vis Exp
 70 , e4279 , 2012
Cells
Intestinal organoids
Enzymes
Collagenase Type 1 : 800 u/ml
Neutral Protease : 0.013%
Medium
DMEM
File
10893.pdf (556.52 KB)
Stem
Mouse
Mouse
Salisbury, E. , Lazard, Z. , Ubogu, E. , Davis, A. and Olmsted-Davis, E.
Transient Brown Adipocyte-Like Cells Derive from Peripheral Nerve Progenitors in Response to Bone Morphogenetic Protein 2. ,
Stem Cells Transl Med
 1 , 874-85 , 2012
Cells
Nerve progenitors
Enzymes
Medium
HBSS
File
11554.pdf (3.51 MB)
Stem
Mouse
Mouse
Takahashi, H. , Haraguchi, N. , Nishikawa, S. , Miyazaki, S. , Suzuki, Y. , Mizushima, T. , Nishimura, J. , Takemasa, I. , Yamamoto, H. , Mimori, K. , Ishii, H. , Doki, Y. and Mori, M.
Biological and Clinical Availability of Adipose-Derived Stem Cells for Pelvic Dead Space Repair. ,
Stem Cells Transl Med
 1 , 803 , 2012
Cells
Adipose derived stem
Enzymes
Medium
DMEM
Stem
Mouse
Mouse, 8-10 week
Chow, K. , Jun, D. , Helm, K. , Wagner, D. and Majka, S.
Isolation & Characterization of Hoechst(low) CD45(negative) Mouse Lung Mesenchymal Stem Cells. ,
J Vis Exp
 56 , e3159 , 2011
Cells
Lung mesenchymal stem
Enzymes
Medium
HBSS
File
10793.pdf (445.89 KB)
Stem
Mouse
Mouse
Shi, C. , Jia, T. , Mendez-Ferrer, S. , Hohl, T. , Serbina, N. , Lipuma, L. , Leiner, I. , Li, M. , Frenette, P. and Pamer, E.
Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-Like Receptor Ligands. ,
Immunity
 34 , 590 , 2011
Cells
Spleen, bone marrow endothelial
Enzymes
Medium
PBS
Stem
Mouse
Mouse, neonatal
Janebodin, K. , Horst, O. , Ieronimakis, N. , Balasundaram, G. , Reesukumal, K. , Pratumvinit, B. and Reyes, M.
Isolation and Characterization of Neural Crest-Derived Stem Cells from Dental Pulp of Neonatal Mice. ,
PLoS ONE
 6 , e27526 , 2011
Cells
Dental pulp stem
Enzymes
Medium
PBS
File
10867.pdf (13.71 MB)

Tissue Tables (references, grouped by tissue type and species)

Adipose/Fat
Adrenal
Bone
Brain
Cartilage
Colon
Endothelial
Epithelial
Eye
Heart
Intestine
Kidney
Liver
Lung
Lymph nodes
Mammary
Miscellaneous
Muscle
Neural
Organoids
Pancreas
Parotid
Pituitary
Prostate
Reproductive
Scales
Skin
Spleen
Stem
Thymus
Thyroid/Parathyroid
Tonsil
Tumor
Note: We have not limited the references listed to only those papers using Worthington enzymes. Generally speaking, the tissue dissociation enzymes offered by Worthington can be used interchangeably for most preparations cited.